SOLVED:One step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3 -phosphoglycerate to give glyceraldehyde 3 -phosphate. The process occurs by phosphorylation with ATP to give 1,3 -bisphosphoglycerate, reaction with a thiol group on the enzyme to give an enzymebound thioester, and reduction with NADH. Suggest mechanisms for all three reactions.

In the first bypass step of gluconeogenesis, the conversion of pyruvate to phosphoenolpyruvate (PEP), pyruvate is carboxylated by pyruvate carboxylase to oxaloacetate, which is subsequently decarboxylated to PEP by PEP carboxykinase (Chapter 14 ). Because the addition of CO2 is directly followed by the loss of CO2, you might expect that in tracer experiments, the ^14 C of ^14 CO2 would not be incorporated into PEP, glucose, or any intermediates in gluconeogenesis. However, investigators find tha

SOLVED: During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step? Select one:a.Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into the cytosol.b.Formation of phosphoenolpyruvate requires both ATP and GTP as an energy source.c.Acetyl CoA is an activator of enzyme pyruvate carboxylase.d.This reaction

PPT - CHAPTER 15 Principles of Metabolic Regulation PowerPoint Presentation - ID:3592444

Mind Luster - Learn Regulation of Glycolysis and Gluconeogenesis