PPT - Protein misfolding diseases (Alzheimer’s) PowerPoint Presentation - ID:2248070

Purification of Hsp104, a Protein Disaggregase

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Protein Misfolding and the Molecular Bases of Alzheimer's and Parkinson's Diseases

A molecular traffic jam may underlie a rare kidney disease and several other protein misfolding disorders

Scientists are turning the process of protein folding into sound

SOLVED: 1) What are the four non-covalent bonds that dictate the protein folding process? List the bonds in terms of their relative strength strongest to weakest (a-d) marks)3 2) Draw the generic structure of an amino acid and label the important chemical groups State what part of the generic amino acid dictates the chemical properties 2 marks) (draw the structure take picture of it and insert the picture here)3) With the aid of a diagram show how peptide bound is formed between two amino acids

Proteins called molecular chaperones (described in Chapter 4 ) assist in the process of protein folding. One class of chaperones found in organisms from bacteria to mammals is heat shock protein 90 (Hsp90). All Hsp90 chaperones contain a 10 amino acid "signature sequence" that allows ready identification of these proteins in sequence databases. Two representations of this signature sequence are shown below. (a) In this sequence, which amino acid residues are invariant (conserved across all speci