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Colon cancer study - Mayo Clinic

Colon cancer study - Mayo Clinic

SOLVED: The anti-fungal drug ketoconazole is more effective if the pH of the patient's stomach is at 2, due to increased solubility of the drug. The structure of ketoconazole, at high pH, is shown on the right. The pka values (6.4 and 3.2) of two nitrogens are indicated. Please answer the following questions. i)What happens to the two nitrogens on ketoconazole at low pH ii) Why does this increase solubility3.26.4

SOLVED: The anti-fungal drug ketoconazole is more effective if the pH of the patient's stomach is at 2, due to increased solubility of the drug. The structure of ketoconazole, at high pH, is shown on the right. The pka values (6.4 and 3.2) of two nitrogens are indicated. Please answer the following questions. i)What happens to the two nitrogens on ketoconazole at low pH ii) Why does this increase solubility3.26.4

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