Precision cell-free DNA extraction for liquid biopsy by ... - Nature
Feb 24, 2020 · We developed a centrifugation-free cfDNA extraction microfluidic chip capable of extracting cfDNA from plasma samples through microfluidic circuits within 15 min under vacuum pressure using an...
Liquid biopsies: Understanding ctDNA and circulating tumor …
Aug 23, 2021 · When cells that aren’t from a tumor shed DNA, it’s considered cell-free DNA – or cfDNA. But how can physicians tell the difference when examining a blood sample? “One way we distinguish the two is that cfDNA are typically longer strands of DNA while ctDNA are typically shorter length fragments,” Lucci says. What are circulating tumor ...
Cell-free DNA analysis in current cancer clinical trials: a review
Jan 13, 2022 · Circulating cell-free DNA (cfDNA) and the tumour-derived DNA fraction, circulating tumour DNA (ctDNA), can be analysed in the context of a liquid biopsy (LB).
Sensitivity, specificity, and accuracy of a liquid biopsy approach ...
May 24, 2021 · Circulating cell-free DNA (cfDNA) has the potential to be a specific biomarker for the therapeutic management of lung cancer patients. Here, a new sequencing error-reduction method based on...
The landscape of cell-free mitochondrial DNA in liquid biopsy for ...
Oct 12, 2023 · In this study we characterized circulating mtDNA using plasma as a liquid biopsy and demonstrated that the mtDNA signal could be retrieved using low coverage WGS and showcased how it can be used to detect the presence of cancer.
Liquid biopsy: current technology and clinical applications
Sep 12, 2022 · Liquid biopsies are increasingly used for cancer molecular profiling that enables a precision oncology approach. Circulating extracellular nucleic acids (cell-free DNA; cfDNA), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs) can be isolated from the blood and other body fluids.
Cancer liquid biopsies by Oxford Nanopore Technologies …
Nov 29, 2024 · CfDNA, a crucial component of liquid biopsy biomarkers, has emerged as a promising noninvasive alternative to tissue biopsy in cancer diagnosis and prognosis prediction . CfDNA fragments are shed into body fluids by dying cells during apoptosis, necrosis, or secretion . The fragments exhibit a wide size distribution, ranging from 20 bp to over ...
Liquid biopsy: current technology and clinical applications
Sep 12, 2022 · Liquid biopsies are increasingly used for cancer molecular profiling that enables a precision oncology approach. Circulating extracellular nucleic acids (cell-free DNA; cfDNA), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs) can be isolated from the blood and other body fluids.
Epigenetic modifications of cfDNA in liquid biopsy for the cancer …
Mar 23, 2024 · Liquid biopsies, encompassing components like circulating cell-free DNA (cfDNA), circulating cell-free RNA (cfRNA), extracellular vesicles (EVs), and circulating tumor cells (CTCs), have emerged as valuable tools for minimally invasive molecular profiling [3].
Application of Cell-free DNA Analysis to Cancer Treatment
Oct 31, 2018 · Liquid biopsy is becoming a valuable tool for molecular testing, for new insights into tumor heterogeneity, and for cancer detection and monitoring. Here, we review the current and potential...
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