Wheat Germ Agglutinin - an overview | ScienceDirect Topics
Wheat Germ Agglutinin (WGA) is a plant-derived lectin that has a high affinity for the endothelial cells of the cerebral capillaries. It is commonly used as a targeting ligand for drug delivery to the blood-brain barrier (BBB) due to its ability to improve brain uptake and enhance the selectivity of drug activity, without causing significant ...
Wheat Germ: Benefits and How to Incorporate it in Your Diet - WebMD
Mar 16, 2023 · There are many benefits of wheat germ. However, it’s important to take note of the following potential risks: Allergic Reactions. Wheat germ contains wheat germ agglutinin.
Effects of wheat germ agglutinin on human gastrointestinal …
Jun 1, 2009 · Wheat germ agglutinin (WGA) is a plant protein that binds specifically to sugars expressed, among many others, by human gastrointestinal epithelial and immune cells. WGA is a toxic compound and an anti-nutritional factor, but recent works have shown that it may have potential as an anti-tumor drug a …
Wheat Germ Agglutinin (WGA): Its Nature, Biological Role
Aug 2, 2024 · Wheat germ agglutinin (WGA) is a protein belonging to the lectins group, present in the wheat germ. The germ contains about 30% proteins and 10–15% lipids that are prone to oxidation and rancidity, and its polyphenol oxidase is prone to react with phenolic substances, leading to the blackening of flour colour and even affecting its shelf life.
Wheat Germ Agglutinin - an overview | ScienceDirect Topics
Wheat germ agglutinin (WGA) is one of the best-characterized wheat proteins due to its ability to bind N-acetylglucosamine (GlcNAc), including the polymeric form, chitin (β-1-4-linked GlcNAc).
The Dietary Intake of Wheat and other Cereal Grains and Their …
Besides gliadin from wheat gluten, the lectin wheat germ agglutinin (WGA) has also been shown to stimulate cells of the immune system and increase intestinal permeability, as we will now discuss further.
Wheat Germ Agglutinin - an overview | ScienceDirect Topics
Wheat germ agglutinin (WGA) is specific for the terminal N-acetyl-β-d-glucosamine residues and N-acetyl-neuraminic acid residues found on mature N-linked oligosaccharides. From: Methods in Cell Biology , 2002
Folding and Homodimerization of Wheat Germ Agglutinin
Sep 9, 2011 · Wheat germ agglutinin (WGA) is emblematic of proteins that specialize in the recognition of carbohydrates. It was the first lectin reported to have a capacity for discriminating between normal and malignant cells.
Wheat Germ Agglutinin—From Toxicity to Biomedical Applications …
Dec 2, 2020 · Wheat germ agglutinin is a hevein class N-Acetylglucosamine–binding protein with specific toxicity and biomedical potential. It is extractable from wheat germ—a low-value byproduct of the wheat industry—using well–established extraction methods based on salt precipitation and affinity chromatography.
The purification, composition and specificity of wheat-germ agglutinin ...
The purification of wheat-germ agglutinin from commercial wheat germ is described. By ion-exchange chromatography three active proteins (isolectins) were separated, one of which was examined in detail. 2. The amino acid composition is unusual, as 20% of residues are half-cystine and 21% are glycine.
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