The ubiquitin system: from cell signalling to disease biology …
Jan 14, 2021 · All eukaryotes—from yeast to humans—express the enzymatic machinery to covalently modify substrate proteins with ubiquitin, a 76 amino-acid residue protein, in a process termed ubiquitination (Fig....
The ubiquitin-proteasome system - PubMed
Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the proteasome. This article recounts the key observations that led to the discovery of …
The Ubiquitin Proteasome System in Genome Stability and Cancer
Dysregulation of the ubiquitin proteasome system (UPS) can contribute to the initiation and progression of neoplastic transformation. In this review we provide an overview of the UPS and summarize its involvement in replication and replicative stress, along with DNA damage repair.
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system ...
Dec 10, 2010 · The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways are integral to cellular protein homeostasis.
The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors
The ubiquitin-proteasome pathway degrades diverse cellular proteins with exquisite specificity. To accomplish this, a highly modular and elaborate ubiquitination machinery is employed to recognize selectively specific substrates.
Cellular quality control by the ubiquitin-proteasome system …
Nov 15, 2019 · We discuss the importance of two major quality control systems responsible for degradation of proteins and organelles in eukaryotic cells: the ubiquitin-proteasome system (UPS) and autophagy.
The Ubiquitin-Proteasome System as a Prospective Molecular …
The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins and therefore plays an essential regulatory role in critical cellular processes including cell cycle progression, proliferation, differentiation, angiogenesis and apoptosis.
Ubiquitin-Proteasome System: Key to Cellular Protein Regulation
Oct 7, 2024 · The ubiquitin-proteasome system (UPS) is a fundamental component in maintaining protein homeostasis, also known as proteostasis, within cells. Proteostasis encompasses the synthesis, folding, trafficking, and degradation of proteins, ensuring cellular function and health.
The ubiquitin–proteasome pathway: on protein death and cell life
Dec 15, 1998 · From an unregulated, non‐specific terminal scavenger process, it has become clear that proteolysis of cellular proteins is a highly complex, temporally controlled and tightly regulated process which plays important roles in a broad array of basic cellular processes.
Structure and Function of the Ubiquitin–Proteasome System: …
Jan 1, 2012 · The ubiquitin–proteasome system. (Ai and Bi) ATP-dependent activation of ubiquitin is catalyzed by E1 enzyme, the ubiquitin-activating enzyme. (Aii and Bii) Transfer of the activated ubiquitin to E2, a ubiquitin-carrier protein (ubiquitin-conjugating enzyme).
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