STAT1 - Wikipedia
STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1.
JAK-STAT signaling pathway - Wikipedia
The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation.
The JAK/STAT signaling pathway: from bench to clinic
Nov 26, 2021 · More than 50 cytokines and growth factors have been identified in the JAK/STAT signaling pathway, such as hormones, interferons (IFN), interleukins (ILs), and colony-stimulating factors. 1...
JAK/STAT pathway: Extracellular signals, diseases, immunity, and ...
The JAK/STAT pathway, a key pathway for protein signaling on the membrane, is crucial in human cells. The dysregulation of this pathway has been considered one of the causes leading to disease progression and tumor growth.
Biology and significance of the JAK/STAT signalling pathways
STAT1 and STAT2 (together with IRF9) were found to form a three-protein transcription complex (ISGF3; interferon-stimulated gene factor-3), which bound to common promoter elements within IFNα-responsive genes (ISRE; interferon-stimulated response element) (5, 30 – 33).
The role of JAK-STAT signaling pathway and its regulators in the …
Jun 21, 2017 · In this review, we represent how the JAK-STAT pathway is generally regulated and then in Th cell subsets in more detail. Finally, we introduce novel targeted strategies as promising therapeutic approaches in the treatment of immune disorders.
STAT1 signal transducer and activator of transcription 1 [ (human)]
AIM2 inflammasome regulated by the IFN-gamma/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease. KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
The JAK-STAT pathway at 30: Much learned, much more to do
Oct 13, 2022 · These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors.
The JAK-STAT pathway at 30: Much learned, much more to do
Oct 13, 2022 · The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals.
Stat1-dependent and -independent pathways in IFN-γ-dependent signaling …
Feb 1, 2002 · However, recent studies have shown that the IFN-γ receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways.