Pathogenesis of Rotavirus diarrhea - PMC - PubMed Central (PMC)
Vacuolation of enterocytes is most prominent on the villus tip, but can occur in enterocytes throughout the villus. The vacuolation is more extensive in mice than in other species. Unlike other species, the villus blunting is limited and very transient in …
Rotavirus Interactions With Host Intestinal Epithelial Cells
Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in young children (<5years) and animals worldwide. RV primarily infects mature enterocytes in the intestinal epithelium causing villus atrophy, enhanced epithelial cell turnover and apoptosis.
Rotaviruses: from pathogenesis to vaccination - PMC
Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection.
The Epithelial Cell Response to Rotavirus Infection1
Oct 15, 1999 · Intestinal epithelial cells are the principal targets of rotavirus infection, but the response of enterocytes to rotavirus infection is largely unknown. We determined that rotavirus infection of HT-29 intestinal epithelial cells results in prompt activation of NF-κB (<2 h), STAT1, and ISG F3 (3 h).
Rotaviruses: From Pathogenesis to Vaccination
Feb 2, 2009 · Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection.
Rotaviruses: From Pathogenesis to Vaccination - ScienceDirect
May 1, 2009 · Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection.
Rotavirus infection - PubMed
Nov 9, 2017 · Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system.
Pathogenesis of Rotavirus diarrhea - ScienceDirect
Nov 1, 2001 · Vacuolation of enterocytes is most prominent on the villus tip, but can occur in enterocytes throughout the villus. The vacuolation is more extensive in mice than in other species. Unlike other species, the villus blunting is limited and …
Pathogenesis of Intestinal and Systemic Rotavirus Infection
Both rotavirus infection and NSP4 promote functional changes in tight junctions between enterocytes that maintain the epithelial barrier (18, 72). The drop in transepithelial resistance induced by either the virus or NSP4 suggests that infection can cause paracellular leakage.
Rotavirus infection | Nature Reviews Disease Primers
Nov 9, 2017 · Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus...