Cross-talk between AMPK and mTOR in regulating energy balance
Recent research demonstrated the possible interplay between mTOR and AMPK signaling pathways. In this review, we will present current knowledge of AMPK and mTOR pathways in regulating energy balance and demonstrate the convergence between these two pathways.
A systems study reveals concurrent activation of AMPK and mTOR ... - Nature
Nov 21, 2016 · We report that AMP-activated protein kinase (AMPK), phosphatidylinositide 3-kinase (PI3K) and mTOR complex 2 (mTORC2) are acutely activated by aa-readdition in an mTORC1-independent manner....
Computational modeling of AMPK and mTOR crosstalk in
Jul 17, 2023 · Here, we develop a computational model of synaptic signaling resulting in the activation of two protein kinases critical in metabolic regulation and cell fate, AMP-Activated protein kinase (AMPK)...
AMPK and mTOR in cellular energy homeostasis and drug targets
This review focuses on our current understanding of the relationship between AMPK and mTORC1 signaling and discusses their roles in cellular and organismal energy homeostasis.
A Double Negative Feedback Loop between mTORC1 and AMPK …
Nov 7, 2019 · We claim that the feedback loops of the AMPK–mTORC1–ULK1 regulatory triangle guarantee the appropriate response mechanism when nutrient and/or energy supply changes. In our opinion, there is an essential double negative feedback loop between mTORC1 and AMPK.
AMPK and mTOR regulate autophagy through direct ... - Nature
Jan 23, 2011 · Under glucose starvation, AMPK promotes autophagy by directly activating Ulk1 through phosphorylation of Ser 317 and Ser 777. Under nutrient sufficiency, high mTOR activity prevents Ulk1...
The role of AMPK-dependent pathways in cellular and molecular ...
Activation of AMPK–mTOR via metformin inhibits the complex activity of the MRCC, which ultimately leads to cell death or inhibition of cell proliferation by growth factors (Cai et al. 2016). Akt kinase is an important kinase in human kinoma, which has three subtypes such as AKT1, AKT2, and AKT3.
Frontiers | Real Talk: The Inter-play Between the mTOR, AMPK, …
Sep 5, 2018 · Strong evidence demonstrates that AMPK negatively regulates the mTOR pathway, but O-GlcNAcylation of AMPK lowers enzymatic activity and promotes growth. On the other hand, AMPK can phosphorylate OGT leading to changes in OGT function.
A possible linkage between AMP‐activated protein kinase (AMPK…
Jan 8, 2003 · In the present study, in order to identify novel mTOR-interacting proteins, yeast two-hybrid screening was carried out using the catalytically inactive mutant of mTOR kinase domain as a bait, revealing the AMPK γ1 subunit as a putative mTOR-interacting protein.
Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in ...
Jan 14, 2021 · AMPK and mTOR influence transcriptional regulation through post-translational modifications of transcription factors and histones as well as epigenetic regulation through the modulation of metabolites produced by intermediary metabolism.
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