The role of glial cells in epilepsy - PubMed
Jan 14, 2014 · New knowledge of the role played by glial cells could increase our understanding of how epilepsy arises and could lead to new treatment strategies. Epilepsy has previously been regarded as exclusively a disturbance in the functioning of neurons and especially of their contact points, the synapses.
Epileptic Seizures: Glia–Neuron Interactions For Better or For …
Dec 2, 2019 · Integrating noradrenergic inputs, and accumulating Ca 2+ over successive failed swimming attempts, radial glia finally relay this cumulative evidence signal to GABAergic neurons that ultimately inhibit the swimming response. This evidence positions radial glia as a main computational component of sensory-motor brain circuits.
Can glial cells save neurons in epilepsy? - PMC - National Center …
Nov 9, 2022 · If the glial cells that support neurons change their function or die in epilepsy, how can the neurons be saved just by targeting neurons? Targeting and preserving glial function, therefore, holds a promise to be an effective therapeutic strategy …
Role of glia in epilepsy-associated neuropathology, …
Jan 7, 2011 · Foresti et al. (2009) recently found that after seizures, the radial glial-like cells at the border between the granule cell layer and the subgranular zone express the CCL2 chemokine receptor (CCR2). This pattern of expression was not observed in control animals.
Neuron–glia interactions in the pathophysiology of epilepsy
In essence, glial cells release a wide range of substances and gliotransmitters to shape the synaptic structure and function with high fidelity, and the disorders with defective synaptic structure and function, including epilepsy, are highly associated with the dysfunctional glial cells.
The role of glial cells in epilepsy | Tidsskrift for Den norske ...
4 days ago · Interactions between glial cells and neurons are crucial for normal brain function. Glial cell dysfunction most likely can contribute to or even cause epilepsy. New knowledge on the role of glial cells in the brain can open up new therapeutic possibilities for epilepsy.
Review and Hypothesis: A Potential Common Link Between Glial Cells ...
Sep 3, 2021 · In this article, we examine the evidence supporting H + as a key modulator of neurotransmission, review data showing that extracellular ATP elicits an increase in H + efflux from glial cells, and describe the potential signal transduction pathways involved in glial cell—mediated H + efflux.
Glia-neuron interactions underlie state transitions to generalized seizures
Aug 23, 2019 · Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia-glia and glia-neuron connections in the generation of epileptic seizures. Subject terms: Neural circuits, Diseases of the nervous system, Gliogenesis.
Neuron-glia interactions in the pathophysiology of epilepsy
The mechanisms by which glia, particularly astrocytes and microglia, may contribute to epilepsy and consequently could be harnessed therapeutically are discussed in this Review. Publication types
Epileptic Seizures: Glia–Neuron Interactions For ... - ScienceDirect
Dec 2, 2019 · This evidence positions radial glia as a main computational component of sensory-motor brain circuits. In other words, it shows that the glial network can mediate input–output transformation through an integrative process within neural networks.
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