Leukemia - StatPearls - NCBI Bookshelf - National Center for ...
Aug 20, 2020 · Leukemia is a heterogeneous group of hematologic malignancies that arise from the dysfunctional proliferation of developing leukocytes. It is classified as either acute or chronic based on the rapidity of proliferation and as myelocytic or lymphocytic based on the cell of origin.
Leukemia adalah nama kelompok penyakit maligna yang dikarakteristikan oleh perubahan kualitatif dan kuantitatif dalam leukosit sirkulasi. Leukemia dihubungkan dengan pertumbuhan abnormal leukosit yang menyebar mendahului sumsum tulang.
Patofisiologi Leukemia - Alomedika
Jul 15, 2024 · Patofisiologi yang mendasari AML adalah terhentinya proses maturasi sel sumsum tulang di tahap awal perkembangan, yang melibatkan aktivasi ataupun inaktivasi gen melalui translokasi kromosom, kelainan genetik, atau epigenetik. [1,3,7]
Pathophysiology of Acute Myeloid Leukemia - PubMed
Summary: Here, we review the pathophysiology of AML with a focus on factors predisposing to AML development, including prior chemo- and radiation therapy, environmental factors, and germline predisposition.
Acute Lymphocytic Leukemia - StatPearls - NCBI Bookshelf
Aug 26, 2023 · Patients with acute lymphocytic leukemia typically present with symptoms related to anemia, thrombocytopenia, and neutropenia due to the replacement of the bone marrow with the tumor. Symptoms can include fatigue, easy or spontaneous bruising/bleeding, and infections.
Pathophysiology | Leukemia
Acute myeloid leukemia (AML) results from the maturational arrest of bone marrow cells in the earliest stages of development. Although the mechanism of cell arrest is still under investigation, many individuals with AML have chromosomal translocations and other genetic abnormalities that activate or inactivate driver genes.
Aug 15, 2012 · The Acute lymphoblastic leukemia (ALL), it produced as a result of a process of malignant transformation of a progenitor lymphocytic cell in the B and T lineages. In ALL, the majority of the cases, the transformation affects the B lineage cells. Leukemia and other cancers share biological characteristics, as clonality.
Chronic myeloid leukemia: pathophysiology, diagnostic parameters, and ...
Aug 14, 2003 · Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display the translocation t(9; 22) that creates the bcr/abl oncogene.
Leukemia - patofisiologi, diagnosis, penatalaksanaan - Alomedika
Jul 15, 2024 · Leukemia adalah suatu keganasan hematologi yang bersifat heterogen dan klonal yang disebabkan oleh disfungsi proliferasi leukosit yang ireguler dan tidak terkendali. Mutasi sel induk hematopoietik atau sel progenitor merupakan etiologi utama leukemia. Leukemia lebih dikenal sebagai kanker darah. [1,5]
The Molecular Pathology of Acute Myeloid Leukemia
Jan 1, 2005 · The pathogenesis of acute myelogenous leukemia (AML) involves an array of molecular alterations that disrupt almost every facet of cell transformation. These processes include the regulation of cell proliferation, differentiation, self-renewal, survival, cell cycle checkpoint control, DNA repair and chromatin stability, and cell dissemination.