Pathology Outlines - Osteosarcoma, NOS
Dec 21, 2022 · Chemotherapy regimens for osteosarcoma based on high dose methotrexate and cisplatin with doxorubicin and ifosfamide (Cancer 2006;106:1154) Low grade osteosarcoma can typically be treated with excision alone and chemotherapy is avoided if final pathology confirms low grade (SICOT J 2018;4:12)
Pathology Outlines - Osteosarcoma
Dec 1, 2016 · Can be secondary osteosarcoma Ossifying fibroma. Benign fibro-osseous neoplasm that is composed of fibrous tissue that contains a variable amount of bony trabeculae or cementum-like spherules Bony trabeculae may be lined by osteoblasts Osteoblasts should not be atypical like the sarcomatous cells of osteosarcoma that produce osteoid
Pathology Outlines - Low grade (central) osteosarcoma
Nov 24, 2020 · High grade areas often show high grade osteosarcoma histology Variant morphology Fibrous dysplasia-like pattern of bone deposition (Cancer 1990;65:1418, Cancer 1993;71:338, Mod Pathol 2010;23:1279) Extensive fibrous zone resembling desmoplastic fibroma (Cancer 1990;65:1418, Cancer 1993;71:338, Mod Pathol 2010;23:1279)
Pathology Outlines - Parosteal osteosarcoma
Conventional osteosarcoma with periosteal spread: Difficult to differentiate from dedifferentiated parosteal osteosarcoma Absence of conventional parosteal osteosarcoma areas Aneuploidy, lack of ring chromosome and less frequent MDM2 and CDK4 amplification (Am J Surg Pathol 2012;36:423, Genes Chromosomes Cancer 2010;49:518)
Pathology Outlines - Osteoblastoma, NOS
Nov 23, 2021 · Giant cell rich osteosarcoma: Neoplastic osteoblasts with marked nuclear pleomorphism, prominent nucleoli and atypical mitoses (J Oral Maxillofac Pathol 2020;24:S67) Abundant spindle cells with marked atypia arranged in a streaming or storiform pattern (Int J Clin Exp Pathol 2015;8:9718) Numerous osteoclast-like giant cells
Pathology Outlines - Chondroblastoma
Chondroblastoma-like osteosarcoma: Histologically, chondroblastoma-like osteosarcoma is characterized by monotonous, minimally to moderately atypical rounded cells with ovoid nuclei resembling chondroblastoma and abnormal osteoid deposition with destruction of the bone (Arch Pathol Lab Med 2020;144:15, Orthopedics 1999;22:337) Negative for H3K36M
Pathology Outlines - Giant cell tumor of bone, NOS
Sep 13, 2021 · Malignant component of a GCTB does not have specific morphological features and may be an undifferentiated sarcoma, fibrosarcoma, chondrosarcoma or osteosarcoma (Am J Surg Pathol 2017;41:1059, J Bone Joint Surg Am 1986;68:1073, Mod Pathol 1989;2:541) Denosumab treated giant cell tumor of bone:
Pathology Outlines - Ewing sarcoma
Second most common malignant bone tumor in children / young adults after osteosarcoma (Cancer 1996;78:532) M:F = 1.5:1 (J Pediatr Hematol Oncol 2008;30:425) Peak incidence in second decade of life Nearly 80% patients 20 years of age Uncommon in patients younger than 5 years and older than 30 years
Pathology Outlines - Extraskeletal osteosarcoma
Jan 6, 2022 · Soft tissue - Extraskeletal osteosarcoma. 30 year old man with chest wall mass (BMC Cancer 2010;10:645) 56 year old man with cutaneous tumor on scar of previous bone graft (Ann Dermatol 2011;23:S160)
Pathology Outlines - Chondrosarcoma (primary, secondary, …
Apr 22, 2021 · Chondroblastic osteosarcoma: If there is significant osteoid formation, then it is osteosarcoma Clinical and radiological correlation is helpful (typically younger patients) Enchondroma: No aggressive features radiologically Cytologically almost indistinguishable from low grade chondrosarcoma