Positive and negative regulators of osteoclast apoptosis - PMC
Survival and apoptosis are of major importance in the osteoclast life cycle. As osteoclasts have short lifespan, any alteration that prolongs their viability may cause enhanced osteoclast activity. Hence, the regulation of OC apoptosis has been recognized as a …
Osteoclast-derived apoptotic bodies couple bone resorption …
Jan 11, 2021 · Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone resorption phase, whereas the functions of osteoclast-derived ABs remain largely unknown....
Role of apoptosis in pathogenesis and treatment of bone-related ...
Osteoclasts apoptosis can be prevented by 1,25 (OH)2 vitamin D3 and parathyroid hormone (PTH) probably through RANKL stimulation or reduction in osteoprotegerin (OPG) expression. It was suggested that PI3K/Akt signaling pathway has a …
Regulation of apoptosis in osteoclasts and osteoblastic cells
Mar 18, 2005 · Understanding the mechanisms and regulation of bone cell apoptosis will enhance our knowledge of bone cell function and help us to develop better therapeutics for the management of osteoporosis and other bone diseases.
Current perspectives on the multiple roles of osteoclasts: …
At the end of the resorptive phase, osteoclasts can undergo apoptosis and release apoptotic bodies whose function remain largely unknown. Curiously, a study revealed that apoptotic bodies from osteoclasts contained RANK and were able to stimulate RANKL reverse signaling, promoting mineralization by osteoblasts in vitro ( Ma et al., 2021 ).
Reduced osteoclast-derived apoptotic bodies in bone marrow ...
Apr 26, 2023 · In our study, we identified a reduction of OC-AB quantity in the bone marrow cavity during the progression of osteoporosis, an apoptotic body-deficient MRL/lpr mice were used to study the...
Osteoclast Apoptosis: The Role of Fas in Vivo and in Vitro
Dec 1, 2003 · Fas-mediated apoptosis is a dominant mechanism for apoptosis. Here, we show the presence of the Fas receptor on mouse, human, avian, and cultured RAW264.7 (murine) derived osteoclasts and the up-regulation of its expression during mouse osteoclast differentiation.
XAF1 promotes osteoclast apoptosis by antagonizing the XIAP …
Jun 7, 2024 · We show that XAF1 depletion enhances osteoclast generation in vitro. XAF1 knockout increases osteoclast number and bone resorption, thereby exacerbating bone loss in both OVX and osteolysis models. Activation of XAF1 with BV6 (a potent XIAP inhibitor) suppresses osteoclast formation.
Regulation of apoptosis in osteoclasts and osteoblastic cells
Mar 18, 2005 · The balance of proliferation, differentiation, and apoptosis of bone cells determines the size of osteoclast or osteoblast populations at any given time. Bone cells constantly receive signals from adjacent cells, hormones, and bone matrix …
Osteoblast-induced osteoclast apoptosis by fas ligand/FAS …
Mar 6, 2015 · In this study, we reveal that osteoblasts are capable of inducing osteoclast apoptosis by FAS ligand (FASL)/FAS signaling. Conditional knockout of FASL in osteoblasts results in elevated osteoclast numbers and activity, along with reduced bone mass, suggesting that osteoblast-produced FASL is required to maintain physiological bone mass.