Hydrogen peroxide induces DNA single- and double-strand breaks …
DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H (2)O (2)) is still controversial. In this work, we studied whether the high levels of H (2)O (2) produced in the thyroid to …
Prompt repair of hydrogen peroxide-induced DNA lesions …
Iron-dependent oxidative DNA damage in vivo by hydrogen peroxide (H2O2, HP) induces copious single-strand(ss)-breaks and base modifications. HP also causes infrequent double-strand DNA breaks, whose relationship to the cell killing is unclear.
Oxidative DNA damage induced by copper and hydrogen peroxide …
Aug 8, 2002 · ROS-induced DNA damage products are both mutagenic and cytotoxic. Hydrogen peroxide (H 2 O 2 ), which generates hydroxy radicals in the presence of transition metal ions, is considered an appropriate model for ROS.
Hydroperoxide-induced DNA damage and mutations
May 30, 2000 · Unrepaired double strand breaks, considered to be the lethal lesion induced by radiation, are not produced by either hydrogen peroxide or alkyl hydroperoxides. However, hydroperoxide treatment results in a higher yield of single strand breaks than radiation when equitoxic doses are compared.
Radiation and hydrogen peroxide induced free radical damage to DNA
Base liberation and backbone breakage of DNA and oligodeoxyadenylic acid induced by hydrogen peroxide and hydroxylamine. Biochim Biophys Acta. 1968 Feb 26;155(2):476–490. [ PubMed ] [ Google Scholar ]
DNA strand breaks produced by oxidative stress in mammalian …
Jan 1, 2001 · These structures were found in DNA of monkey kidney cells exposed to hydrogen peroxide, iron nitrilotriacetate or ascorbate, all species known to favor a cellular pro-oxidant status. The method employed to measure 3' phosphoglycolate was the 32P-postlabeling assay.
Hydrogen peroxide-induced DNA damage is independent of …
Jan 1, 2001 · Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions. In cells undergoing oxidative stress, DNA damage may result from attack by .OH radicals produced by the Fenton reaction, and/or by nucleases activated by nuclear calcium.
Hydrogen Peroxide-Induced DNA Damage and Repair through the ... - PubMed
Oct 10, 2018 · Using single cell gel electrophoresis, a dose-related increase was found for both DNA breaks and oxidative lesions (formamidopyrimidine DNA glycosylase-sensitive sites) upon exposure of hADMSCs to hydrogen peroxide.
Hydrogen peroxide induces DNA single- and double-strand breaks …
Sep 1, 2009 · DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H 2 O 2) is still controversial. In this work, we studied whether the high levels of H 2 O 2 produced in the thyroid to oxidize iodide could induce DNA modifications.
Hydrogen peroxide: effects on DNA, chromosomes, cell cycle …
May 1, 2001 · Induction of DNA damage by hydrogen peroxide DNA damage and repair in FA cells treated with H 2 O 2 were evaluated by measuring both 8-OHdG in DNA (HPLC-EC analysis) and DNA breaks in intact nuclei (SCGE assay).
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