High-mobility group - Wikipedia
High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. [1]
HMG-box - Wikipedia
In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding. [1] The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins.
The high mobility group box: the ultimate utility player of a ...
High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG-box DNA binding domain and general mechanisms of DNA binding and bending have been known for …
HMG chromosomal proteins in development and disease - PMC
The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence …
HMG Protein - an overview | ScienceDirect Topics
HMG proteins, such as HMGA1 and HMGA2, are highly versatile proteins that lack a defined structure, allowing them to interact with various molecules and modify substrates. They play essential roles in binding DNA, remodeling chromatin, facilitating transcription, and regulating cellular processes in tissues and during development.
High Mobility Group Box 1: Biological Functions and Relevance ...
In the early 1970s, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and named high-mobility group (HMG) proteins. High-mobility group box 1 (HMGB1) is the most studied HMG protein that detects and coordinates cellular stress response.
HMG chromosomal proteins in development and disease
The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence …
HMG Nuclear Proteins: Linking Chromatin Structure to Cellular ...
The ‘High Mobility Group’ (HMG) non-histone proteins occupy a unique niche in vertebrate biology. The distinctive constellation of ways they coordinate and facilitate DNA-directed nuclear processes, and thereby influence cellular phenotypes, …
The HMG-1 box protein family: classification and functional ...
Jan 1, 2001 · The abundant and highly-conserved nucleoproteins comprising the high mobility group-1/2 (HMG-1/2) family contains two homologous basic domains of about 75 amino acids. These basic domains, termed HMG-1 boxes, are highly …
HMG proteins: dynamic players in gene regulation and
Core histones package the genome into nucleosomes and control its accessibility to transcription factors. High mobility group proteins (HMGs) are, after histones, the second most abundant chromatin proteins and exert global genomic functions …