FLOT2 promotes nasopharyngeal carcinoma progression through …
Jan 19, 2024 · Our results found that FLOT2 promotes the development of NPC by inhibiting TGF-β signaling pathway via stimulating the expression of CD109 by stabilizing STAT3, which provides a potential therapeutic strategy for NPC treatment.
Flot2 promotes tumor growth and metastasis through modulating …
May 1, 2017 · Our results showed that Flot2 significantly promoted the invasion, migration, proliferation and metastasis of HCC in vitro and in vivo through modulating cell cycle and inducing EMT, and this activity was mediated by up-regulation of Twist as a result of Raf/MEK/ERK1/2 pathway activation.
FLOT2 upregulation promotes growth and invasion by …
Apr 9, 2021 · In this study, we find that FLOT2 interacts and positively correlates with EphA2, and maintains the stability of EphA2, which accounts for Akt and NF-κB activation by FLOT2 in gliomas. Besides, FLOT2 alteration shows no influences on EGFR, suggesting the heterogeneity of FLOT2 in different tissues.
Flotillin-2 regulates epidermal growth factor receptor activation ...
Dec 5, 2022 · We identified over a hundred novel Cbl interactors, and a secondary siRNA screen found that knockdown of Flotillin-2 (FLOT2) led to increased phosphorylation and degradation of EGFR upon EGF stimulation in HeLa cells.
Flot2 promotes tumor growth and metastasis through modulating …
May 1, 2017 · Flotillin-2 (Flot2) is a highly conserved and ubiquitously expressed protein that resides on the cytoplasmic side of the cell membrane within specific cholesterol rich microdomains. Some studies have reported that overexpression …
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A
Nov 21, 2024 · HNRNPH1 is highly expressed in NPC and stabilizes FLOT2 mRNA through an m6A-dependent mechanism. HNRNPH1 interacts with METTL14 to prevent its degradation by STUB1 E3 ligases, leading to increased m6A modification of FLOT2 by METTL14. Additionally, IGF2BP3 was shown to recognize the m6A modification on FLOT2 mRNA, further stabilizing it.
FLOT2 upregulation promotes growth and invasion by interacting …
Apr 9, 2021 · In this study, we explored the expression and functions of FLOT2 in gliomas and found that FLOT2 was upregulated and could promote cell growth and invasion in glioma via inhibition of apoptosis, induction of cell cycle, and activation of EMT.
FLOT2 - Wikipedia
Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. [5][6] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae / lipid raft domains that tether growth factor receptors linked to signal transduction pathways.
HDAC6-mediated deacetylation of FLOT2 maintains stability and ...
May 28, 2024 · The K211 site of FLOT2 undergoes acetylation modification, and HDAC6 mediates deacetylation at this site, inhibiting proteasomal degradation of FLOT2 and maintaining its stability and tumor-promoting function in nasopharyngeal carcinoma.
Flotillin-2 promotes cell proliferation via activating the c …
Mar 3, 2021 · Our results revealed that FLOT2 promotes NPC cell proliferation by suppressing miR-33b-5p, to maintain proper levels of c-Myc, and upregulate BCAT1trancription. Therefore, the FLOT2/miR-33b-5p/c-Myc/BCAT1 axis is a potential therapeutic target for NPC.