Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein ...
Jun 22, 2012 · FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a candidate gene for syndromal and nonspecific forms of X-chromosome-linked mental retardation (XLMR). However, its function during development remains unclear.
Fibroblast growth factor 13 is a microtubule-stabilizing protein ...
Jun 22, 2012 · FGF13 is enriched in axonal growth cones and interacts directly with microtubules. Furthermore, FGF13 polymerizes tubulins and stabilizes microtubules. The loss of FGF13 impairs neuronal polarization and increases the branching of axons and leading processes.
We show that FGF13 acts intracel-lularly as a microtubule-stabilizing protein required for axon and leading process development and neu-ronal migration in the cerebral cortex. FGF13 is en-riched in axonal growth cones and interacts directly with microtubules. Furthermore, FGF13 polymerizes tubulins and stabilizes microtubules.
FGF13 Gene - GeneCards | FGF13 Protein | FGF13 Antibody
Dec 9, 2024 · FGF13 (Fibroblast Growth Factor 13) is a Protein Coding gene. Diseases associated with FGF13 include Developmental And Epileptic Encephalopathy 90 and Intellectual Developmental Disorder, X-Linked 110. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
2258 - Gene ResultFGF13 fibroblast growth factor 13 [ (human)]
Increased expression of fibroblast growth factor 13 in cortical lesions of the focal cortical dysplasia. FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule-stabilizing effect.
Fibroblast Growth Factor (FGF) 13 - ScienceDirect
Sep 25, 2024 · Fibroblast Growth Factor (FGF) 13, also referred to as FGF homologous factor (FHF) 2, is a member of the FGF11 subfamily that is characterized as having sequence similarities to classical FGF receptor (FGFR)-binding FGFs, but functionally do not bind FGFRs.
Fibroblast growth factor 13 [Homo sapiens] - Protein - NCBI
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and ce... Also Known As: DEE90, FGF-13, FGF2, FH...
Fibroblast Growth Factor (FGF) 13 - PubMed
Fibroblast Growth Factor (FGF) 13, also referred to as FGF homologous factor (FHF) 2, is a member of the FGF11 subfamily that is characterized as having sequence similarities to classical FGF receptor (FGFR)-binding FGFs, but functionally do not bind FGFRs.
FGF13 fibroblast growth factor 13 - NIH Genetic Testing …
Jun 17, 2024 · The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
Fibroblast Growth Factor Homologous Factor 13 Regulates Na
Aug 4, 2011 · We demonstrated that isoforms of FGF13 are the predominant FHFs in adult mouse ventricular myocytes. FGF13 binds directly to, and colocalizes with, the Na V 1.5 Na + channel in the sarcolemma of adult mouse ventricular myocytes.