Lumbar endplate microfracture injury induces Modic-like …
Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better understand pathophysiological mechanisms and screen therapeutics.
Lumbar endplate microfracture injury induces Modic-like …
Surgically-induced endplate (EP) microfracture increased IVD degeneration, spinal cord substance P (subP), vertebral remodeling, pain-like behaviors, and resulted in Modic-like EP changes.
RESULTS: Surgically-induced EP microfracture with PBS and TNFa injection induced IVD degeneration with decreased IVD height and MRI T2 signal, vertebral remodeling, and secondary damage to cartilage EP adjacent to the injury.
Lumbar endplate microfracture injury induces Modic-like …
BACKGROUND CONTEXT: Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better understand pathophysiological mechanisms and screen therapeutics.
Lumbar endplate microfracture injury induces Modic-like …
Jan 30, 2023 · BACKGROUND CONTEXT : Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to...
Lumbar endplate microfracture injury induces Modic-like …
Apr 1, 2023 · Results: Surgically-induced EP microfracture with PBS and TNFα injection induced IVD degeneration with decreased IVD height and MRI T2 signal, vertebral remodeling, and secondary damage to...
Lumbar endplate microfracture injury induces Modic-like …
Jan 27, 2023 · Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better understand pathophysiological mechanisms and …
The magnetic resonance imaging-based vertebral bone quality …
Apr 30, 2024 · Albert et al. found that when the lumbar disk degenerates, the stress on the functional unit of the spine redistributes, and the load on the endplate increases, leading to microfracture of the endplate. Recurrent microfractures of the endplate may be the leading cause of MC formation.
Lumbar endplate microfracture injury induces Modic-like …
Jan 27, 2023 · Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – an in vivo rat model Dalin Wang Alon Lai
The effects of lumbar fusion and non-fusion surgery on the …
Jul 1, 2022 · At present, the causes of MCs are still unclear, but endplate microfracture is considered as an important biomechanical factor for the occurrence of MCs [7, 17].