How I treat disseminated intravascular coagulation
Feb 22, 2018 · Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction.
Disseminated intravascular coagulation in acute leukemia
Clinical complications may range from localized thrombosis to bleeding of varying degrees of severity because of disseminated intravascular coagulation (DIC). Life-threatening bleeding is frequent in acute leukemias, particularly in acute promyelocytic leukemia (APL).
Acute Disseminated Intravascular Coagulation (DIC)
Sep 18, 2024 · Acute DIC results from an acute coagulation trigger (e.g., sepsis). This leads to abrupt and exuberant depletion of coagulation factors, leading to hemostatic imbalances. This chapter is predominantly about acute DIC – which is more immediately relevant to …
Disseminated Intravascular Coagulation (DIC) - Cleveland Clinic
Aug 30, 2023 · Disseminated intravascular coagulation (DIC) is a rare blood clotting disorder that can cause organ damage and uncontrollable bleeding. DIC is a complication of different serious medical conditions that can be life-threatening if you don’t receive treatment.
Disseminated Intravascular Coagulation - StatPearls - NCBI Bookshelf
May 1, 2024 · Disseminated intravascular coagulation (DIC) can be defined as a widespread hypercoagulable state that can lead to micro- and macrovascular clotting and compromised blood flow, ultimately resulting in multiple organ dysfunction syndrome.
Management of hemostatic complications in acute leukemia: …
Given the complexity of coagulopathy in this population, we will focus on four main issues related to hemostatic complications in adult patients with acute leukemia, including platelet transfusion, disseminated intravascular coagulation (DIC), L-asparaginase-related hypofibrinogenemia, and the use of antifibrinolytic agents.
Disseminated intravascular coagulation at diagnosis is a strong ...
Oct 6, 2016 · Disseminated intravascular coagulation (DIC) is associated with VTE and bleeding in acute promyelocytic leukemia and acute lymphoblastic leukemia. 7-12 Although DIC has also been reported in AML, no data exist on the relationship between DIC and …
Diagnosis and treatment of disseminated intravascular coagulation (DIC ...
Disseminated intravascular coagulation (DIC) is categorized into bleeding, organ failure, massive bleeding, and non-symptomatic types according to the sum of vectors for hypercoagulation and hyperfibrinolysis. ... This form of DIC is often seen in patients with leukemia, such as acute promyelocytic leukemia (APL), obstetric diseases, or aortic ...
Disseminated intravascular coagulation in acute leukemia: …
Results: A total of 36 patients (29%) were diagnosed with DIC according to expert opinion, a method regarded as the de facto gold standard. Leukemia-associated DIC is characterized by rare manifestation of organ failure because of thrombosis and no relevance of the platelet count for the diagnosis.
DIC is common in patients with acute leukemia, with prevalence ranging from 17 to 100% in acute promyelocytic leukemia (APL) and 8.5 to 25% in acute lymphoblastic leukemia (ALL) and non-APL acute myeloid leukemia (AML).