Complex Relationship Between Cardiac Fibroblasts and …
In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.
Three in a Box: Understanding Cardiomyocyte, Fibroblast, and …
Cardiomyocyte-Cardiac Fibroblast-Macrophage Interactions. Cardiomyocytes and interspersed interstitial cells such as fibroblasts are adjacently situated in the heart and can interact via the release of paracrine factors, direct cell-cell interactions and indirectly through ECM .
Cardiac fibroblasts and mechanosensation in heart development, …
Nov 14, 2022 · In this Review, we describe the mechanical role of cardiac fibroblasts during cardiac development, with an emphasis on the capacity of fibroblasts to ‘perceive’ mechanical cues and to regulate...
Cardiomyocyte-fibroblast crosstalk in the postnatal heart
Mar 22, 2023 · Cardiac fibroblasts are considered the most abundant non-cardiomyocyte cell type of the heart (Tallquist and Molkentin, 2017). Located within the myocardial interstitium and in proximity to capillaries and blood vessels, they have critical functions in extracellular matrix (ECM) deposition, maintenance, and remodeling.
Intramyocardial Fibroblast - Myocyte Communication - PMC
Cardiac fibroblasts are emerging as key components of normal cardiac function as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in extracellular matrix …
Cardiomyocyte-fibroblast interaction regulates ferroptosis and …
Mar 15, 2024 · We demonstrated that cardiac fibroblasts (CFs) protect cardiomyocytes from ferroptosis through paracrine effects and direct cell-cell interaction. CFs show strong resistance to ferroptosis due to high ferritin expression.
Three in a Box: Understanding Cardiomyocyte, Fibroblast, and …
Apr 2, 2019 · The interplay of innate immune cells with cardiac fibroblasts and cardiomyocytes is emerging as a crucial platform to help our understanding and, importantly, to allow the development of effective interventions sufficient to minimize …
Cardiomyocyte-fibroblast interaction regulates ferroptosis and …
Feb 7, 2023 · We demonstrate that cardiac fibroblasts (CFs) protect cardiomyocytes from ferroptosis through paracrine factors and direct cell-cell interaction. CFs show strong resistance to ferroptosis due to high ferritin expression.
Myocyte-fibroblast communication in cardiac fibrosis and …
This review will focus on (i) mechanisms of myocyte-fibroblast communication and their effects on disease features such as cardiac fibrosis and arrhythmias as well as (ii) methods being used and currently developed in this field.
Myocyte-fibroblast communication in cardiac fibrosis and …
May 1, 2016 · Myocyte-fibroblast interactions impact heart function and disease phenotypes such as cardiac fibrosis and arrhythmias. These interactions occur via paracrine, extracellular matrix protein, electrical, and mechanical junction modalities.
- Some results have been removed