Physiology, Bile Secretion - StatPearls - NCBI Bookshelf
Sep 26, 2022 · Transporter proteins within the canalicular membrane use energy to secrete molecules into bile against concentration gradients. Through this active transport, osmotic and electrochemical gradients are formed. When conjugated bile salts enter the canaliculus, water follows by osmosis.
Biliary System Anatomy and Functions - Johns Hopkins Medicine
The transportation of bile follows this sequence: When the liver cells secrete bile, it is collected by a system of ducts that flow from the liver through the right and left hepatic ducts. These ducts ultimately drain into the common hepatic duct.
Bile acid transporters in health and disease - PMC
Over the past 5-10 years, much has been learned about the mechanisms of bile acid transport and homeostasis, mainly due to the identification and cloning of membrane transporter genes, and by new findings about the means of regulating their expression in health and disease.
Bile acid transporters: structure, function, regulation and ...
Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function.
Bile Acid Transporters: Structure, Function, Regulation and ...
Apr 3, 2007 · The ileal bile acid transport system with its remarkable substrate specificity and various regulatory mechanisms offers enormous potential as a valuable target for cholesterol lowering therapy by controlling enterohepatic circulation with specific inhibitors.
Hepatobiliary transport in health and disease - PMC
Bile salts, cholesterol and phosphatidylcholine are secreted across the canalicular membrane of hepatocytes into bile by ATP-binding cassette (ABC) transporters. Secretion of bile salts by ABCB11 is essential for bile flow and for absorption of lipids and fat-soluble vitamins.
Bile Formation and Secretion - PMC - PubMed Central (PMC)
Bile is a complex aqueous secretion that originates from hepatocytes and is modified distally by absorptive and secretory transport systems in the bile duct epithelium. Bile then enters the gallbladder where it is concentrated or is delivered directly to the intestinal lumen.
Hepatobiliary Transport: Molecular Mechanisms of Development …
Aug 1, 1998 · Separate hepatic and ductular transport mechanisms allow for rapid regulation of bile volume and composition required for changing physiologic needs. The array of transport proteins...
Bile acid transporters - ScienceDirect
Dec 1, 2009 · In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation.
Overview of Biliary Function - Hepatic and Biliary Disorders
The liver uses active transport to secrete bile salts into the canaliculus, the cleft between adjacent hepatocytes. Canalicular transport is the rate-limiting step in bile formation. Once secreted, bile salts draw other bile components (particularly sodium and water) into the canaliculus by osmosis.