Reductive Amination of Aldehydes and Ketones with Sodium ...
May 31, 1996 · Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates.
Reductive Amination, and How It Works - Master Organic …
Sep 1, 2017 · This is called reductive amination and avoids the problem of multiple alkylations. One common reducing agent for this purposes is sodium cyanoborohydride (NaBH 3 CN) which can selectively reduce imines in the presence of aldehydes.
Sodium triacetoxyborohydride - Organic Chemistry Portal
Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran and occasionally in acetonitrile.
Amine synthesis by reductive amination (reductive alkylation)
Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran and occasionally in acetonitrile.
Reductive Amination of Aldehydes and Ketones with Sodium ...
Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran and occasionally in acetonitrile.
Sodium triacetoxyborohydride - Wikipedia
Sodium triacetoxyborohydride is a milder reducing agent than sodium borohydride or even sodium cyanoborohydride. It reduces aldehydes but not most ketones. It is especially suitable for reductive aminations of aldehydes and ketones. [2] [3] [4]
Reductive amination of aldehydes and ketones by using sodium ...
Jan 1, 1990 · Sodium triacetoxyborohydride is a reagent of choice in the reductive amination of aldehydes and saturated aliphatic ketones with primary and secondary amines.
A Review on the Use of Sodium Triacetoxyborohydride in the Reductive …
Sep 15, 2006 · Density Functional Theory Study on the Selective Reductive Amination of Aldehydes and Ketones over Their Reductions to Alcohols Using Sodium Triacetoxyborohydride. ACS Omega 2022, 7 (34) , 30554-30564. https://doi.org/10.1021/acsomega.2c04056
REDUCTIVE AMINATION: USING SODIUM TRIACETOXYBOROHYDRIDE AND SODIUM ...
Jan 8, 2023 · Sodium triacetoxyborohydride (STAB) is one such selective reducing agent for direct reductive amination. It is a mild reagent that possesses remarkable selectivity as a reducing agent. The steric and electron-withdrawing effects of the three acetoxy groups stabilize the boron-hydrogen bond and are responsible for its mild reducing properties.
Sodium Triacetoxyborohydride - MilliporeSigma
Sodium triacetoxyborohydride (NaBH(OAc) 3) is particularly effective in reductive aminations due to its large scope, mildness, and selectivity. 1 It is preferred to sodium cyanoborohydride (NaBH 3 CN) in many applications due to reduced toxicity of the side products formed, and better yields and reproducibility during synthesis.