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  1. Rotavirus - Overview

    Verified Expert
    A contagious virus that cause inflammation of the stomach and intestines leading to diarrhea.
    How common is condition?
    Common (More than 200,000 cases per year in US)
    Is condition treatable?
    Treatable by a medical professional
    Does diagnosis require lab test or imaging?
    Often requires lab test or imaging
    Time taken for recovery
    Can last several days or weeks
    Is condition preventable by vaccine?
    Usually preventable by vaccine
    How is condition transmitted?
    Transmitted through fecal-oral route
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    Causes

    Verified Expert

    • The causes include:
    • Rota virus is infective and spreads through faecal-oral route
    • Spreads easily among infants and young children
    • The rotavirus is spread through faeces shed from a sick person to another and into the environment
    • The shed virus enters the susceptible person’s mouth to cause infection
    • The virus is spread by contaminated hands, food, objects and water

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    Symptoms

    Verified Expert
    Contact your provider if experiencing new, severe, or persistent symptoms.

    Once you get rotavirus, it takes about 2 days for the symptoms to appear and the commonly observed symptoms include:

    • Vomiting
    • Watery diarrhea that can last from 3 to 8 days
    • Watery diarrhea that can last from 3 to 8 days
    • Loss of appetite and
    • Dehydration
    • Crying without tears
    • Lethargy and irritability

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    Chapter 19: Rotavirus | Pink Book | CDC - Centers for Disease Control ...
    CDC

    Diagnosis

    Verified Expert
    One or more of these tests may be recommended by your medical provider.
    Rotavirus is diagnosed based on the symptoms and physical examination and a lab test is done to confirm the diagnosis.

    Common tests & procedures

    Stool test: Done for rapid detection of rotavirus antigen in stool specimens.

    Enzyme immunoassay: Done to check for the presence of the virus.

    Reverse transcriptase polymerase chain reaction: Done to test the strain of rotavirus.

    See more
    Microsoft Start Health
    Source: Focus Medica. For informational purposes only. Consult a medical professional for advice. | Disclaimer: Opinions are from external health professionals and should not be considered as Microsoft's opinion or a substitute for professional help. Consult a health professional for medical advice.
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    Table of Contents
    Overview
    Causes
    Symptoms
    Diagnosis
    Health guide
     
  1. Wikipedia
    https://en.wikipedia.org › wiki › Rotavirus

    Rotavirus - Wikipedia

    Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. There are nine species of the genus, referred to as A, B, C, D, F, G, H, I and J. Rotavirus A is the most common species, and these rotaviruses cause more …

  2. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Rotavirus RNA Replication Requires a Single-Stranded …

    Rotaviruses, members of the family Reoviridae, are the major cause of acute dehydrating diarrhea in infants and young children ().The rotavirus genome consists of 11 segments of double-stranded (ds) RNA and is contained in the …

  3. ICTV
    https://ictv.global › ... › sedoreoviridae › rota…

    Genus: Rotavirus | ICTV

    Rotavirus genomic RNA sequences are A+U rich (58–67%). The segments are completely base-paired, and the positive-sense strand contains a 5′-terminal cap structure (m 7 GpppG (m) GC), but lacks a polyadenylation signal near its 3′-end.

  4. CDC
    https://www.cdc.gov › pinkbook › hcp › table-of-contents

    Chapter 19: Rotavirus | Pink Book | CDC - Centers for Disease …

  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    Rotavirus - StatPearls - NCBI Bookshelf - National …

    Jan 2, 2023 · Rotavirus RNA is present in the cerebrospinal fluid of some patients with central nervous system symptoms, which may indicate a direct viral invasion. Rotavirus may lead to alterations in calcium homeostasis.

  6. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Viroplasms: Assembly and Functions of Rotavirus Replication …

  7. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    RNA-Binding Activity of the Rotavirus Phosphoprotein NSP5 …

  8. PNAS
    https://www.pnas.org › doi

    Structural basis of rotavirus RNA chaperone …

    Oct 6, 2021 · Rotavirus genome comprises 11 distinct RNAs, and successful replication requires the incorporation of all 11 RNAs into a virion. The RNA chaperone NSP2 binds viral transcripts, regulating their interactions with each …

  9. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Rotavirus RNA replication and gene expression - PubMed

  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Nucleolin–RNA interaction modulates rotavirus replication