Induction and analysis of nephrotoxic serum nephritis in mice
The nephrotoxic serum nephritis (NTN) model is an integral part of experimental glomerulonephritis (GN) research. Here, we discuss how the murine NTN model can be induced and effectively used to mimic an immune complex-mediated GN.
Murine Nephrotoxic Nephritis as a Model of Chronic Kidney …
Mar 5, 2018 · NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD parameters including albuminuria, glomerular filtration rate (GFR), mesangial expansion, and renal fibrosis.
The effect of mycophenolate mofetil on podocytes in nephrotoxic serum ...
Aug 29, 2023 · The goal of this study was to characterize podocyte biology during MMF treatment in nephrotoxic serum (NTS) nephritis (NTN). NTN was induced in three-week old wild-type mice.
Induction and Analysis of Nephrotoxic Serum Nephritis in Mice
Jan 1, 2014 · The nephrotoxic serum nephritis (NTN) model is an integral part of experimental glomerulonephritis (GN) research. Here, we discuss how the murine NTN model can be induced and effectively used to mimic an immune complex-mediated GN.
Nephrotoxic nephritis and glomerulonephritis: animal model …
This review aims to provide insight on a 'suitable' model for nephrotoxic nephritis and glomerulonephritis (NTN GN) and relate its experimental validity to humans. The BALB/c NTN murine model and Wistar Kyoto (WKY) rat have held …
Urine Proteome Analysis in Murine Nephrotoxic Serum Nephritis
Sep 24, 2009 · The nephrotoxic serum (NTS) nephritis model is a well-characterized model for the study of immune complex kidney diseases [1,2,3,4]. NTS is generated by immunizing sheep with kidney glomerular extracts. In the passive model, NTS is administered to nonsensitized mice.
The TNF-derived TIP peptide activates the ... - Kidney International
Apr 21, 2018 · We demonstrate that the TNF-derived TIP peptide, mimicking the lectin-like domain of the molecule, which does not affect the cytokine’s antibacterial effects, significantly blunts renal inflammation and proteinuria in murine nephrotoxic nephritis.
Complement alternative pathway activation in the autologous …
Jun 6, 2012 · We examined whether mice with targeted deletion of the gene for factor B (fB −/− mice) and selective deficiency in the alternative pathway of complement are protected from injury in the nephrotoxic serum (NTS) nephritis model of antibody-mediated glomerulonephritis.
Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic …
May 16, 2024 · We performed non-accelerated nephrotoxic serum nephritis (NTN) as the CKD model in BAFF KO (B6.129S2- Tnfsf13btm1Msc /J), BAFF-R KO (B6 (Cg)- Tnfrsf13ctm1Mass /J) and wildtype (C57BL/6J) mice to analyze the BAFF/BAFF-R system in anti-glomerular basement membrane (GBM) disease using high throughput RNA sequencing.
Innate and adaptive immunity in experimental glomerulonephritis: …
May 11, 2016 · The nephrotoxic serum nephritis (NTS) model is a mouse model which is commonly used to study a type of immune complex-mediated, rapidly progressive glomerulonephritis (GN). It is induced by the injection of antibodies raised either in rabbits or sheep that are directed against the glomerular basement membrane (GBM).