Drug-Induced Acute Kidney Injury : Clinical Journal of the ... - LWW
Medications are a common cause of AKI, especially for patients admitted to hospital wards and the intensive care unit. Although drug-related kidney injury occurs through different mechanisms, this review will focus on three specific types of tubulointerstitial injury.
Stop if AKI due to rhabdomyolysis. Stop if patient develops unexplained / persistent muscle pain. May accumulate leading to increased risk of bleeding. Routine blood testing does not detect those people at high risk of bleeding. Consider withholding, …
Drug-Induced Nephrotoxicity | AAFP
Sep 15, 2008 · Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR < 60 mL per minute per 1.73...
Nephrotoxic Medications - StatPearls - NCBI Bookshelf
Jun 21, 2023 · Nephrotoxic medications can elicit damage to the kidney via various mechanisms, including alteration in its structure and function. When evaluating the primary etiologies in renal injury, the incidence of drug-induced toxicity has accounted for 20% of all-cause incidents.
The term ‘nephrotoxic’ should be used with caution. Few medications truly have direct toxic effects on the kidneys, but several have the potential to impair renal function if used under certain circumstances, such as where the patient has a degree of chronic kidney disease in conjunction with hypovolaemia and acute illness.
Overview of Antibiotic-Induced Nephrotoxicity - PMC - PubMed …
Drug-induced nephrotoxicity accounts for up to 60% of cases of acute kidney injury (AKI) in hospitalized patients and is associated with increased morbidity and mortality in both adults and children. Antibiotics are one of the most common causes of drug-induced nephrotoxicity.
The 6R’s of drug induced nephrotoxicity - BMC Nephrology
Apr 3, 2017 · Drug-induced nephrotoxicity is increasingly recognized as a significant contributor to kidney disease including acute kidney injury (AKI) and chronic kidney disease (CKD). Nephrotoxicity has a wide spectrum, reflecting damage to different nephron segments based upon individual drug mechanisms.
Pharmacology behind Common Drug Nephrotoxicities - PMC
Drug-induced nephrotoxicity in adults is approximately 14%–26% in prospective cohort studies of AKI, whereas 16% of hospitalized AKI is due to drugs in the pediatric population (1 – 4). Drug-induced nephrotoxicity is more common in hospitalized patients, …
Acute kidney injury associated with nephrotoxic drugs in critically …
Nephrotoxic drugs frequently cause acute kidney injury (AKI) in adult intensive care unit (ICU) patients. However, there is a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI.
Clinical risk fac-tors for nephrotoxicity have been identified for some drugs. Approach the use of any poten-tially nephrotoxic drugs with caution in patients at high risk, and analyze the risks and benefits. Polypharmacy increases the risk. Take precautions.