Recent advances in integrated microfluidics for liquid biopsies …
Dec 1, 2022 · Recent advances in microfluidic technology have integrated separation, purification, and detection, allowing for high-throughput, high-sensitivity, and high-controllability detection of specific biomarkers in liquid biopsies.
Recent advances in microfluidic methods in cancer liquid biopsy
Jul 23, 2019 · Zilberman and Sonkusale 30 proposed an optical microfluidic system to diagnose gastric cancer using saliva as a liquid biopsy. Their microfluidic system with embedded sensors quantified the body fluids by-products (NH 3 and CO 2 ) of a urea-processing enzyme secreted from Helicobacter pylori .
Microfluidic-based technologies in cancer liquid biopsy: …
Dec 1, 2023 · Liquid biopsy is a non- or minimally invasive method that analyzes biological molecules existing in body fluids as biomarkers. Liquid biopsy has revolutionized cancer diagnosis and management by providing availability of repeated sampling and regular monitoring.
Recent advances in droplet‐based microfluidics in liquid biopsy …
When adapted in the clinic for liquid biopsy, the developed droplet microfluidic can successfully detect the expression of miRNA with a calculated amount of 0.66–7.66 zmol per CTCs. However, this method includes cell lysis inside the droplets, which could induce high background noise.
Microfluidics for Liquid Biopsies: Recent Advances, Current …
Mar 8, 2021 · Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis. Sensors 2023, 23 (23) , 9432. https://doi.org/10.3390/s23239432.
Microfluidic Exosome Analysis toward Liquid Biopsy for Cancer
In this article, we review the state-of-the-art development of microfluidic technologies for exosome isolation and molecular characterization with emphasis on their applications toward liquid biopsy–based analysis of cancer.
Sensor-Integrated Microfluidic Approaches for Liquid Biopsies ...
Feb 28, 2020 · In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), …
The Use of Microfluidic Technology for Cancer Applications and Liquid …
Aug 10, 2018 · Liquid biopsy has gained attention due to its non-invasive sampling of tumor tissue and ability to serially assess disease via a simple blood draw over the course of treatment. Among the leading technologies developing liquid biopsy solutions, microfluidics has recently come to …
Latest advances and perspectives of liquid biopsy for cancer ...
May 15, 2023 · Microfluidic chips have been successfully applied in cancer diagnosis and monitoring, given that they can lead to the effective separation and analysis of cancer-derived substances such as extracellular vesicles (EVs), circulating tumour cells (CTCs) and circulating DNA (ctDNA), proteins and other metabolites.
Microfluidic biosensors for biomarker detection in body fluids: a …
Dec 5, 2024 · Early detection of cancer significantly improves patient outcomes, with biomarkers offering a promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have emerged as a powerful tool for detecting these biomarkers in body fluids, providing enhanced sensitivity, specificity, and rapid analysis. This review focuses on recent advances in microfluidic biosensors from 2018 ...