Translation in Prokaryotes - PMC
This review summarizes our current understanding of translation in prokaryotes, focusing on the mechanistic and structural aspects of each phase of translation: initiation, elongation, termination, and ribosome recycling.
Molecular mechanisms of eukaryotic translation fidelity and …
Jul 1, 2023 · In this review, we summarize the fidelity mechanism of protein translation process centered on eukaryotic ribosomes, and further discuss the effects of protein mistranslation on organisms.
Dynamic basis of fidelity and speed in translation: Coordinated ...
As the universal machine that transfers genetic information from RNA to protein, the ribosome synthesizes proteins with remarkably high fidelity and speed. This is a result of the accurate and efficient decoding of mRNA codons via multistep mechanisms during elongation and termination stages of translation.
Fidelity at the molecular level: lessons from protein synthesis
In this review, we focus on the fidelity of codon recognition in tRNA selection and translation termination, beginning with a discussion of the biological implications of translational fidelity for organismal fitness.
The Fidelity of Translation - ScienceDirect
Jan 1, 1983 · One type of error involves a “readthrough” translation of certain termination codons in both prokaryotes and eukaryotes by a normal tRNA. The other type, demonstrated more recently, is an initiation error taking place in certain in vitro systems deficient in ribosome-releasing factor.
Translation in Prokaryotes - PubMed
Sep 4, 2018 · This review summarizes our current understanding of translation in prokaryotes, focusing on the mechanistic and structural aspects of each phase of translation: initiation, elongation, termination, and ribosome recycling.
Translational fidelity and mistranslation in the cellular response to ...
Aug 8, 2017 · Protein translation and the corresponding machinery are centrally positioned to assess the severity of stress and modulate the stress response, and quality control (QC) probably plays an important role in the maintenance of cellular homeostasis beyond the …
The fidelity of translation initiation: reciprocal activities of eIF1 ...
Dec 15, 2005 · The fidelity of translation depends on accurate selection of the correct reading frame during initiation. In eukaryotes, this process involves at least 11 eukaryotic initiation factors (eIFs).
Molecular mechanisms of eukaryotic translation fidelity and …
Jul 1, 2023 · In recent years, advances in modern biotechnology, especially the development of cryo-electron microscopy and single-molecule techniques, have enabled a clearer understanding of the mechanisms of protein translation fidelity.
Translation fidelity coevolves with longevity - PMC
Jul 13, 2017 · Currently, the mechanisms responsible for maintaining translation fidelity are best understood in prokaryotes or lower eukaryotes. Deeper understanding of protein translation in mammals is needed to begin addressing the mechanisms responsible for interspecies differences in translation fidelity among mammals.