Cross-tissue human fibroblast atlas reveals myofibroblast …
Sep 19, 2024 · Fibroblasts, known for their functional diversity, play crucial roles in inflammation and cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on fibroblast cells from 517 human samples, spanning 11 …
Cancer-associated fibroblast subtypes modulate the tumor …
Nov 8, 2024 · We identify three distinct CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). Large-cohort tissue analysis reveals significant shifts in CAF...
Fibroblast inflammatory priming determines regenerative versus …
Dec 8, 2022 · Single-cell multi-omics reveal that uninjured velvet fibroblasts resemble human fetal fibroblasts, whereas back skin fibroblasts express inflammatory mediators mimicking pro-fibrotic adult human and rodent fibroblasts.
GitHub - immunogenomics/fibroblastatlas: The Fibroblast Atlas
Jan 11, 2021 · This repository describes the Fibroblast Atlas, an effort to establish a cross-tissue taxonomy for fibroblast states. The preprint below describes the first version of this atlas, with a focus on fibroblasts in human inflammatory diseases.
A Distinguished Roadmap of Fibroblast Senescence in Predicting ...
3 days ago · A) Schematic of the tumor cell-fibroblast coculture system with transwells. B) Percentage of SA-βgal + fibroblasts following coculture with oeCDC6 PANC-1 or PATU-8988 cells (scale bar: 100 µm). C) Representative plots and percentages of p16 + fibroblasts in coculture with oeCDC6 PANC-1 or PATU-8988 cells. D) qRT-PCR analysis showing the ...
Cell types. Fibroblast. Atlas of plant and animal histology.
a) Fibroblasts form different populations according to the body location: rostral or caudal, ventral or dorsal. The position is important for fibroblast function, and they somehow know the spatial location. For example, fibroblasts are thought to be involved in the induction of hair follicles, sweat glands, and feathers in birds.
Early events marking lung fibroblast transition to profibrotic state …
Apr 23, 2023 · We identified fibroblast subclusters, genes and pathways associated with early disease. Immunofluorescence assays validated the role of MOXD1 early in fibrosis. We identified four distinct fibroblast subgroups, including one marking the normal-to-profibrotic state transition.
Cross-tissue human fibroblast atlas reveals myofibroblast
Oct 14, 2024 · In this study, we conduct comprehensive single-cell RNA sequencing analyses on fibroblast cells from 517 human samples, spanning 11 tissue types and diverse pathological states. We identify distinct fibroblast subpopulations …
Fibroblast Subpopulations in Systemic Sclerosis: Functional ...
Jun 1, 2024 · Fibroblasts constitute a heterogeneous population of cells. In this study, we integrated single-cell RNA-sequencing and bulk RNA-sequencing data as well as clinical information to study the role of individual fibroblast populations in systemic sclerosis (SSc).
Fibroblast - Wikipedia
Fibroblasts are the most common cells of connective tissue in animals. Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum (RER).