Structural basis for FGF hormone signalling | Nature
Jun 7, 2023 · To reveal the molecular mechanism underpinning the coreceptor role of HS, we solved cryo-electron microscopy structures of three distinct 1:2:1:1 FGF23–FGFR–αKlotho–HS quaternary complexes...
The FGF family: biology, pathophysiology and therapy - PMC
FGFs have a homologous core region that consists of 120–130 amino acids ordered into 12 antiparallel β-strands (β1–β12) flanked by divergent amino and carboxyl termini (FIG. 1a). In general, primary sequence variation of the N- and C-terminal tails of FGFs accounts for the different biology of the ligands 13 (FIG. 1b).
The Fibroblast Growth Factor signaling pathway - PMC
FGFR is a receptor tyrosine kinase of ∼800 amino acids with several domains including three extracellular immunoglobulin-like domains (I, II, and III), a transmembrane domain (TM), and two intracellular tyrosine kinase domains (TK1 and TK2). SP indicates a …
Fibroblast Growth Factors: Biology, Function, and Application for ...
Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation.
Decoding FGF/FGFR Signaling: Insights into Biological Functions …
Dec 18, 2024 · The crystal structure of FGF was published in 2003 (PDB ID—1NUN) . FGF10 also possesses the characteristic β-trefoil structure with 12 antiparallelly oriented β-strands. Similar to FGF7, the β1 strand of FGF10 is longer, and the β10 and β11 strands are less organized compared to FGF1 and FGF2. The first five amino acid residues at the N ...
Exploring mechanisms of FGF signalling through the lens of
Feb 13, 2013 · Structural data has provided insight into the molecular mechanisms that modulate fibroblast growth factor (FGF) signalling to generate distinct biological outputs in development, tissue...
Fibroblast growth factor 2 - ScienceDirect
Sep 1, 2024 · Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation.
Crystal Structure of Fibroblast Growth Factor 9 Reveals Regions ...
Crystal structures of FGF1 (7), FGF2 (7-9), and FGF7 (10), have revealed a common core FGF structure consisting of three copies of a four-stranded β-sheet, known as a β-trefoil fold. All FGFs contain N- and C-terminal segments outside the β-trefoil core.
Structural basis for FGF hormone signalling - PubMed
Our structural and biochemical data overturn the current symmetric FGFR dimerization paradigm and provide blueprints for rational discovery of modulators of FGF signalling 2 as therapeutics for human metabolic diseases and cancer.
The FGF family: biology, pathophysiology and therapy
Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are...
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