The Use of Colchicine in Pericardial Diseases
Dec 4, 2019 · Colchicine has since been the focus of many observational and randomized studies for pericardial diseases. In fact, it is now a class IA medication to treat acute and recurrent pericarditis. 2 Despite the gastrointestinal possible side-effects, colchicine is considered a safe anti-inflammatory drug. The focus of this expert review is to:
Colchicine in Cardiovascular Disease: In-Depth Review
Dec 29, 2021 · It is considered standard-of-care therapy for pericarditis, and several clinical trials have evaluated its role in postoperative and postablation atrial fibrillation, postpericardiotomy syndrome, coronary artery disease, percutaneous coronary interventions, and …
Acute pericarditis: Treatment and prognosis - UpToDate
- Causes of acute pericarditis - Drug therapy acute and recurrent pericarditis; RELATED TOPICS. Patient education: Pericarditis (Beyond the Basics) Acute pericarditis: Clinical presentation and diagnosis; Biology of warfarin and modulators of INR control; Cardiac tamponade; Constrictive pericarditis: Diagnostic evaluation
Treatment of Acute and Recurrent Idiopathic Pericarditis
Apr 23, 2013 · In the open-label Colchicine in Acute Pericarditis (COPE) trial, 120 patients with a first episode of acute pericarditis were randomized to receive colchicine (0.5–1.0 mg daily for 3 months after 1–2 mg on the first day) plus aspirin (800 mg every 6–8 hours for 7–10 days, then tapered over 3–4 weeks) or aspirin alone. 12 The rate of ...
Management of Acute and Recurrent Pericarditis:
The COPE (COlchicine for acute PEricarditis) trial, including patients with a first episode of acute pericarditis, showed that colchicine significantly reduced symptom persistence at 72 h and recurrence rate .
Effects of colchicine on pericardial diseases: a review of the ...
In the subset of pericardial diseases, colchicine has been shown to be effective in recurrent pericarditis and post-pericardiotomy syndrome (PPS).
A Randomized Trial of Colchicine for Acute Pericarditis
Oct 17, 2013 · In a multicenter, double-blind trial, eligible adults with acute pericarditis were randomly assigned to receive either colchicine (at a dose of 0.5 mg twice daily for 3 months for patients...
Colchicine, as adjunctive therapy to NSAIDs, is effective in reducing the number of pericarditis recurrences in patients with recurrent pericarditis or acute pericarditis. However, evidence is based on a limited number of small trials.
Acute pericarditis: Update on diagnosis and management - PMC
Colchicine at 500 μg twice per day (if >70 kg) or 500 μg once per day (if <70kg) for 3 months more than halves the risk of recurrence (number needed to treat = four).
Colchicine for pericarditis - PubMed
Colchicine (0.5mg twice daily for patients >70kg or once daily for those weighing less) in addition to standard anti-inflammatory therapy, in either acute or recurrent pericarditis, may hasten the response to anti-inflammatory therapy and reduce the subsequent risk of recurrences.