African Swine Fever Virus (ASFV): Biology, Genomics and …
The rich genetic diversity of ASFV is not only promoted by the sylvatic cycle alone but is also enhanced by the domestic cycle through the open borders and uncontrolled movement of pigs and swine products.
African Swine Fever Virus: An Emerging DNA Arbovirus
May 12, 2020 · Within the tick life cycle, ASFV can be transmitted sexually from infected male to female (17, 32), transovarially from infected female to offspring (15, 27, 37), and maintained transstadially through the various life stages [(28, 29, 38, 39); see Figure 2].
Infographic: The Lifecycle of African Swine Fever Virus
Jan 13, 2020 · Since the late 2000s, ASFV is thought to have gained a foothold in Europe, especially the eastern part of the continent where infections often spill over to small-scale pig farms. It’s not yet clear whether ASFV has infected wild boar populations in China or other East Asian countries it has spread to.
An Update on African Swine Fever Virology - PMC - PubMed …
ASFV entry into host cells depends on several factors, such as temperature, cholesterol, energy, and vacuolar pH [16,21]. In summary, ASFV has been reported to internalize via two endocytic pathways: Macropinocytosis and clathrin-mediated endocytosis (CME).
African Swine Fever Virus: An Emerging DNA Arbovirus
May 13, 2020 · The high morbidity and mortality associated with ASFV, the lack of an efficacious vaccine, and the complex makeup of the ASFV virion and genome as well as its lifecycle, make this pathogen a serious threat to the global swine industry and national economies.
Structure of African Swine Fever Virus and Associated Molecular ...
Sep 5, 2021 · This review summarizes the recent findings on ASFV structure, the molecular mechanism of ASFV infection and immunosuppression, and ASFV-encoded proteins to provide comprehensive proteomic information for basic research on ASFV.
Structure of the recombinant RNA polymerase from African Swine …
Feb 21, 2024 · Here, we present methods to produce recombinant ASFV RNA polymerase, functional assays to screen for inhibitors, and high-resolution cryo-electron microscopy structures of the ASFV RNAP in...
African Swine Fever Virus (ASFV): Biology, Genomics and …
Nov 15, 2021 · African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus Asfivirus and Asfarviridae African suids family. The disease is among the most devastating pig diseases worldwide including Africa.
ASFV is one of the most complex viruses known to date. Its genome varies between 170 and 190 kb, encoding more than 150 proteins that are involved in various stages of ASFV life cycle, including...
New insights into the role of endosomal proteins for African swine ...
Jan 26, 2022 · African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropinocytosis.
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