Circulating Tumor Cells: Strategies for Capture, Analyses, and ...
In this review, we highlight the latest CTC capture and analyses technologies, and discuss in vitro strategies for culturing and propagating CTC. Keywords: Circulating tumor cells, CTC, clinical biomarkers, cCAF. Cancer remains among the most common causes of …
High throughput capture of circulating tumor cells using an …
Sep 15, 2013 · In this microfluidic platform, a combination of microfluidic deterministic lateral displacement array and affinity-based cell capture architecture, allows for the high efficiency cancer cell enrichment and continuous high throughput and purity cancer cell capture.
Detection of circulating tumor cells: opportunities and challenges
Circulating tumor cells (CTCs) are cells that shed from a primary tumor and travel through the bloodstream. Studying the functional and molecular characteristics of CTCs may provide in-depth knowledge regarding highly lethal tumor diseases.
Efficient capture of circulating tumor cells with low molecular …
May 20, 2022 · We have designed folic acid-biotin conjugates with different linkers for the capture of folate receptor (FR) + tumor cells spiked into whole blood, and application of the same technology to...
Circulating Tumor Cell Detection Technologies and Clinical Utility ...
Schematic representation of circulating tumor cells (CTCs) detaching from primary tumor, intravasating into the bloodstream, and circulating to colonize distant organs after extravasating where they create secondary metastasis.
Bait-trap chip for accurate and ultrasensitive capture of living ...
May 1, 2023 · Using an in-situ rolling circle amplification (RCA) method, branched aptamers were easily modified onto the NCage structure, and served as “baits” to enhance the multi-interactions between CTC biomarker and chips, leading to ultrasensitive …
Enhanced capture system for mesenchymal‑type circulating tumor cells ...
Oct 4, 2024 · CellSearch, the only approved epithelial cell adhesion molecule (EpCAM)‑dependent capture system approved for clinical use, overlooks circulating tumor cells (CTCs) undergoing epithelial‑mesenchymal transition (EMT‑CTCs), which is considered a crucial subtype responsible for metastasis.
Circulating Tumor Cells: Strategies for Capture, Analyses, and ...
In this review, we highlight the latest CTC capture and analyses technologies, and discuss in vitro strategies for culturing and propagating CTC. Circulating tumor cells (CTCs) play a central role in tumor dissemination and metastases, which are ultimately responsible for most cancer deaths.
Harnessing virus flexibility to selectively capture and profile rare ...
Jul 12, 2024 · Immunostaining of captured circulating tumor cells precisely determines breast cancer subtypes with a diagnostic accuracy of 91.07%. Our study reveals the power of viral mechanical attributes in designing surfaces with superior target binding and …
High-Efficiency Capture of Individual and Cluster of Circulating Tumor ...
Jun 11, 2016 · Effective isolation of circulating tumor cells (CTCs) has great significance for cancer research but is highly challenged. Here, we developed a microchip embedded with a three-dimensional (3D) PDMS scaffold by a quadratic-sacrificing template method for high-efficiency capture of CTCs.