![](/rp/kFAqShRrnkQMbH6NYLBYoJ3lq9s.png)
Shigella - Medical Microbiology - NCBI Bookshelf
Infection is initiated by ingestion of shigellae (usually via fecal-oral contamination). An early symptom, diarrhea (possibly elicited by enterotoxins and/or cytotoxin), may occur as the organisms pass through the small intestine. The hallmarks of shigellosis are bacterial invasion of the colonic epithelium and inflammatory colitis.
Shigellosis - StatPearls - NCBI Bookshelf
Feb 26, 2024 · Shigellosis is an acute enteric infection caused by shigellae, a facultative gram-negative, anaerobic bacillus. Shigellae can be transmitted by the fecal-oral route or by direct person-to-person contact.
Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation …
While studying the mechanisms of Shigella pathogenesis in vivo has proven difficult, Shigella infection, in particular using the S. flexneri species, has become one of the most widely used paradigms of host-bacterial interaction in cellular models of infection.
Molecular Mechanisms of Shigella Pathogenesis; Recent Advances
Jan 26, 2023 · Shigella species uses attachment, invasion, intracellular motility, toxin secretion and host cell interruption mechanisms, causing mild diarrhoea, haemorrhagic colitis and haemolytic uremic syndrome diseases in humans through the expression of effector delivery systems, protein effectors, toxins, host cell immune system evasion and iron uptake ...
Molecular Mechanisms of Shigella Pathogenesis; Recent …
Jan 26, 2023 · Shigella strains employ three main mechanisms to prevent host cell death and provide the replication niche for bacterial infection. IpaB effector has been shown to induce host cell cycle arrest via targeting Mitotic Arrest Deficient 2 Like 2 (MAD2L2, an anaphase inhibitor) protein to prevent the host cell turnover.
Frontiers | Cellular Aspects of Shigella Pathogenesis: Focus on the ...
Mar 30, 2016 · While studying the mechanisms of Shigella pathogenesis in vivo has proven difficult, Shigella infection, in particular using the S. flexneri species, has become one of the most widely used paradigms of host-bacterial interaction in cellular models of infection.
Shigella Pathogenesis: New Insights through Advanced …
In the arms race between Shigella and the host immune system, Shigella has developed highly sophisticated mechanisms to subvert host cell processes in order to promote infection, escape immune detection, and prevent bacterial clearance.
The pathogenesis of Shigella flexneri infection: lessons from in …
Shigella flexneri is a Gram-negative facultatively intracellular pathogen responsible for bacillary dysentery in humans. More than one million deaths occur yearly due to infections with Shigella spp. and the victims are mostly children of the developing world.
Shigella Manipulates Host Immune Responses by Delivering …
Because the host transcriptional program plays a pivotal role in triggering inflammation and eliminating bacterial infection, Shigella overcomes this defense mechanism by delivering a subset of T3SS effector proteins that regulate gene expression and counteract host immune responses.
Molecular mechanisms of Shigella effector proteins: a common …
Jun 19, 2022 · Infection with wild-type Shigella that possesses a T3SS leads to the death of B cell in both invaded and non-invaded B lymphocytes. Signaling by TLR-1 mediates apoptosis, and it is indicated that TLR-1/2 heterodimer generates death signal by IpaD.
- Some results have been removed