Centromere - Wikipedia
The centromere links a pair of sister chromatids together during cell division. This constricted region of chromosome connects the sister chromatids, creating a short arm (p) and a long arm (q) on the chromatids.
Centromere - Definition, Function and Types - Biology Dictionary
Apr 27, 2017 · Centromere Definition. The centromere is the point on a chromosome where mitotic spindle fibers attach to pull sister chromatids apart during cell division. When a cell seeks to reproduce itself, it must first make a complete copy of each of its chromosomes, to ensure that their daughter cell receives a full complement of the parent cell’s DNA.
Centromere - National Human Genome Research Institute
4 days ago · The centromere appears as a constricted region of a chromosome and plays a key role in helping the cell divide up its DNA during division (mitosis and meiosis). Specifically, it is the region where the cell’s spindle fibers attach.
Centromere- Definition, Structure, Position, Types, Functions
Aug 3, 2023 · Centromeres are crucial in the development of a new cell. The centromere acts as a binding location for the two replicated chromosomes, known as sister chromatids, when the chromosomes are copied. Centromere dysfunction results in …
Centromere | chromosome, DNA, replication | Britannica
Centromere, structure in a chromosome that holds together the two chromatids (the daughter strands of a replicated chromosome). The centromere is the point of attachment of the kinetochore, a structure to which the microtubules of the mitotic spindle become anchored.
The variation and evolution of complete human centromeres
Apr 3, 2024 · To understand evolutionary change, we selected six chromosomes and sequenced and assembled 31 orthologous centromeres from the common chimpanzee, orangutan and macaque genomes. Comparative analyses...
The molecular basis for centromere identity and function
Nov 25, 2015 · To achieve accurate segregation, chromosomes rely on a specialized region known as the centromere. The centromere recruits the kinetochore, which is a proteinaceous macromolecular structure that...
Complete genomic and epigenetic maps of human centromeres
Human centromeres are located within large arrays of tandemly repeated DNA sequences known as alpha satellite (αSat), which often span millions of base pairs on each chromosome.
Centromere Structure and Function - PMC - PubMed Central (PMC)
The centromere is the genetic locus that specifies the site of kinetochore assembly, where the chromosome will attach to the kinetochore microtubule. The pericentromere is the physical region responsible for the geometry of bi-oriented sister kinetochores in metaphase.
Chromosome Segregation in Mitosis: The Role of Centromeres
One structure that plays a critical role in ensuring that this does not occur is the centromere. The centromere was first described by German biologist Walter Flemming in the 1880s as the...