Regulation of antiviral immune response by African swine fever virus (ASFV)
The knowledge gap of ASF virus (ASFV) pathogenesis and immune evasion is the main factor to limit the development of safe and effective ASF vaccines. Here, we will summarize the molecular mechanisms of how ASFV interferes with the host innate and adaptive immune responses.
Modulation of Host Antiviral Innate Immunity by African Swine …
Oct 26, 2022 · ASFV encodes more than 150 ORFs, and previous studies have shown that multiple proteins, including A238L, DP96R, MGF360, MGF505-7R and A276R, are involved in promoting viral replication by regulating the innate immune …
Regulation and Evasion of Host Immune Response by African …
Host immune responses known to be regulated by African swine fever virus (ASFV). aND means not done. ASFV regulates host immune responses, including the type I interferon response, the inflammatory response, apoptosis, antigen presentation, and cellular immune response.
Host Innate and Adaptive Immunity Against African Swine Fever …
ASFV has a significant impact on the adaptive immune response, including both humoral and cellular immunity, effectively evading immune clearance and inhibiting immune memory. B and T lymphocytes are the primary cells involved in these responses.
Frontiers | Regulation and Evasion of Host Immune Response by …
Sep 7, 2021 · Host immune responses known to be regulated by African swine fever virus (ASFV). The type I interferon (IFN)-mediated antiviral response plays an indispensable role in viral clearance. Host pattern recognition receptors (PRRs) can discern pathogen-associated molecular patterns (PAMPs), such as viral RNA and DNA (Rai et al., 2021).
Innate immune escape and adaptive immune evasion of African …
Oct 1, 2023 · ASFV infection leads to impaired cellular immune responses and enhanced lymphocyte apoptosis, leading to lymphocytopenia. Cytotoxic T cells, a type of memory helper T cell, play a crucial role in the cellular immune response against ASFV infection.
African Swine Fever Virus E184L Protein Interacts with Innate Immune …
Feb 15, 2023 · Here, we report that ASFV E184L protein inhibits host innate immune response via targeting the stimulator of IFN genes (STING)-mediated signaling pathway in both human embryonic kidney HEK-293T cells and porcine pulmonary alveolar macrophages.
Immune Escape Mechanism and Vaccine Research Progress of …
ASFV has evolved the ability to manipulate host immune responses by encoding many immune escape genes, including regulation of IFN expression, inhibition of autophagy, and apoptosis.
Multifaceted Immune Responses to African Swine Fever Virus ... - PubMed
Though several promising vaccine candidates have been described, more key scientific challenges remain unsolved. Here, we provide an overview of the current knowledge in innate and adaptive immune responses elicited by ASFV infection and different kinds of vaccine candidates.
Mucosal and cellular immune responses elicited by nasal and ...
Aug 31, 2023 · Both immunogen groups can effectively stimulate the host to produce ideal humoral, mucosal, and cellular immune responses, providing a theoretical basis for subsequent functional studies, such as immunogens challenge protection and elucidation of the pathogenic mechanism of ASFV.