Autophagy, frequently referred to as the self-recycling process ... There are two complexes including mTORC1 comprised of Raptor, Deptor, mTOR, mLST8 and PRAS40, and mTORC2 comprised of Rictor, Deptor ...

The mTOR complex 1 (mechanistic Target of Rapamycin complex 1, in short ‘mTORC1’) is the central component of a protein network that senses whether a cell has access to sufficient nutrients. Therefore ...

3.5 BCAAs supplementation did not affect mTORC1 activity in response to exercise intervention The T389 of 70 kDa Ribosomal S6 Kinase (p70S6K) can be phosphorylated by mTORC1. Unexpectedly, p70S6K ...

Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of the University of Electronic ...

Finally, we display that glutamine deprivation promotes autophagy and that ammonia is an inhibitor of autophagy. Overall, we identify a relationship between glutamine metabolism and inflammatory ...

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are ...