Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

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Patrick Mahomes will “most likely” play today against the Houston Texans despite a high-ankle sprain, according to coach Andy Reid. Mahomes’ status has been the most-tracked storyline of the week for Chiefs' fans and NFL bettors alike.

Here are our five best NFL Week 16 picks against the spread, including one over/under total to wager on this upcoming weekend.

NFL odds are balanced between home and road teams, with eight of each being favored in the season's third-to-last regular season week. The two largest of the Week 16 NFL spreads are home teams Buffalo (-14 vs.

NFL slate has several divisional matchups and plenty of playoff implications, with only three weeks remaining in the 2024-25 regular season. Three games will be played before 1 p.m. ET on Sunday, but there are still 11 afternoon games to bet on and enjoy during the holidays.