These azoles antifungals target a crucial enzyme for sterol biosynthesis, called CYP51. While not fungi, both Leishmania species have biochemical similarities to fungi in their plasma membrane ...

These azoles antifungals target a crucial enzyme for sterol biosynthesis, called CYP51. While not fungi, both Leishmania species have biochemical similarities to fungi in their plasma membrane ...

Elevated plasma membrane cholesterol levels have been implicated as attenuating ... but did not increase total sterol concentration. Treatments with empty methyl- -cyclodextrin (M CD) pulled about 20% ...

Sterols are amphipathic lipids based on the steroid ring structure but with a polar hydroxyl (OH group) on one of the 6-membered rings. Sterols are also known as steroid alcohols, an example of ...

But this process only happens in certain microdomains that are rich in sterols and oleosins along the membrane. The Brookhaven team hypothesizes that sterol is essential to the formation of these ...

These azoles antifungals target a crucial enzyme for sterol biosynthesis, called CYP51. While not fungi, both Leishmania species have biochemical similarities to fungi in their plasma membrane ...