drives loss of vascular integrity that causes vascular leakage, which results in a drop in blood pressure (and in severe cases septic shock) and reduced organ perfusion that can cause organs to fail.
Hepatopulmonary Syndrome: Update on Recent Advances in Pathophysiology, Investigation, and Treatment
It is due to vasodilation and angiogenesis in the pulmonary vascular bed ... and subsequent increased production of NO, which causes vasodilation. In addition, increased phagocytosis of bacterial ...
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