In diabetic kidney disease, fat accumulates in the kidneys, leading to lipotoxicity and kidney damage. A recently published ...

Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell through blood vessels and bodily fluids: special proteins that keep their ...

Water flow plays a surprising role in the formation of new blood vessels as zebrafish develop, RIKEN researchers have ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ...

Both receptors are expressed by liver resident macrophages, Kupffer cells (KCs). Methods To determine the role of KCs and interactions with PRRs in NASH, mice were fed a methionine choline deficient ...

1 Liver Research Laboratory ... Somatostatin may influence hepatic fibrosis with mediators produced by Kupffer cells. The aim of this study is to investigate the role of somatostatinergic and cytokine ...

The possible role of virus has not ... Microscopical examination of the liver revealed diffuse cholestasis, focal necrosis with inflammation, Kupffer-cell mobilization with phagocytosis of bile ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

Solid evidence validates the described pipeline for identification of TCRs from single-cell datasets for the generation of TCR transgenic mice, while obviating the need for generation of T-cell lines ...

Cells ‘read’ these gradients to figure out their position and role in the developing tissue. For example, high levels might tell a cell to become a nerve cell, medium levels tell it to become ...