A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

The researchers discovered that the RNAP transcribing the mRNA deploys two different anchors to rope in the ribosome and ensure a solid footing and start of protein synthesis. This is similar to a ...

University of Würzburg researchers identified a fast mRNA degradation mechanism driven by m6A modifications. This process ...

The researchers discovered that the RNAP transcribing the mRNA deploys two different anchors to rope in the ribosome and ensure a solid footing and start of protein synthesis. This is similar to a ...

Insights into protein synthesis processes in prokaryotes and eukaryotes are crucial for advancements in genetics, ...

This important study by Bi and colleagues employed a clever genetics screen to uncover the role of the GidB rRNA methylase in translation fidelity, under certain conditions, in Mycobacterium smegmatis ...

It was previously clear that the ribosome must somehow find the right place on the right mRNA to begin protein synthesis. To me, this suggested a potentially very long search before the molecules ...

Tumour development relies on new protein synthesis, which takes place in ribosomes. Identifying enzymes regulating protein synthesis in gastric cancer has been a key focus for a team of ...

Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation ...

In cell-free protein synthesis, cells are ripped apart at very high pressure, making it possible to extract the components such as ribosomes needed for protein production. Then, cellular energy ...