Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This ...

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living ...

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby ...

Researchers have discovered a process that breaks down mRNA molecules in the human body particularly efficiently. This could be useful, for example, in the treatment of cancer.

Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body ...

University of Würzburg researchers identified a fast mRNA degradation mechanism driven by m6A modifications. This process ...

Endocrine therapy against the estrogen receptor (ER) is widely used for the treatment of ER+ breast cancer. Selective estrogen receptor degraders (SERDs) compete directly with estrogen for ER binding ...

mediating the signaling pathways for protein degradation and the maintenance of cellular homeostasis. These proteins act as ...

The hotspot at chr3q28 sits between the GMNC and osteocrin (OSTN) genes. They are involved in DNA replication and dendritic ...

The study aims to identify mRNAs targeted by these proteins for degradation and translation repression and assess their impact on metabolic pathways including mitochondrial function and alternative ...

What remains now is to see if the protein degradation approach of targeting the IL-4/IL-13 pathways works out in a similar manner. Preclinical testing has yielded this theory, but now the company ...