Selective protein degradation by the ubiquitin–proteasome pathway is a fundamental regulatory strategy that fulfils essential roles in various cellular processes. In recognition of the central ...
What remains now is to see if the protein degradation approach of targeting the IL-4/IL-13 pathways works out in a similar manner. Preclinical testing has yielded this theory, but now the company ...
Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This ...
Targeted protein degradation (TPD) has emerged as a novel therapeutic modality that harnesses intracellular proteasomal and lysosomal protein-degradation pathways for selective elimination of ...
We investigate protein degradation processes using chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific ...
mediating the signaling pathways for protein degradation and the maintenance of cellular homeostasis. These proteins act as ...
Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body ...
From manipulating host molecules to concealing their presence in the host’s body, microbes employ a wide range of tactics to ...
University of Würzburg researchers identified a fast mRNA degradation mechanism driven by m6A modifications. This process ...
Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described ... cells and directs it towards degradation.
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