Perianal fistulas cause significant morbidity and diminish patients' quality of life. Consequences of perianal fistulas include perianal drainage, pain, abscess formation, dyschezia, dyspareunia ...

Among those patients, around 1 in 3 will develop perianal fistulas. Perianal fistulas are tunnels that develop near the anus. They can cause pain and drainage and make the patient more likely to ...

This time we separated them out and found it's the anti-TNF medicines specifically that prevent perianal fistulas." Around 40,000 children in the United States suffer from Crohn's disease.

The odds of PFCs were significantly reduced in association with early anti-TNFα therapy (odds ratio, 0.18). (HealthDay News) — For pediatric patients with Crohn disease, early anti-tumor ...

European regulators have recommended Alofisel, a new advanced therapy to treat complex perianal fistulas in patients with Crohn’s disease. The treatment is now just a step away from being the ...

Alofisel (darvadstrocel) has been cleared by the Ministry of Health, Labour and Welfare (MHLW) for the treatment of complex perianal fistulas in patients with non-active or mildly active luminal ...

Jennifer Jones, MD, Advanced Fellow in Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota William Tremaine, MD, Professor of Medicine ...

For pediatric Crohn disease patients, early anti-TNFα therapy is beneficial in preventing the development of perianal fistula complications.

Early treatment of pediatric Crohn’s disease with anti-tumor necrosis factor medications can substantially reduce the risk of perianal fistulas, a particularly debilitating complication of Crohn ...