ALZFORUM1d
Microglia Drive Neurodegeneration in Niemann-Pick Type C
Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...
Le Lézard1d
Dx&Vx, From mRNA Vaccines to Nanoparticle Vaccines era of Next-Generation Vaccines
The COVID-19 pandemic has fundamentally transformed global healthcare systems and vaccine technologies. The accelerated approval and rapid distribution of mRNA vaccines introduced a new paradigm in ...
Macrophages, not T cells, may hold key to predicting which melanoma patients are more likely to respond to immunotherapy
An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that ...
Study advances possible blood test for early-stage Alzheimer's disease, explains why women may be at higher risk
Declining blood levels of two molecules that occur naturally in the body track closely with worsening Alzheimer's disease, ...
pharmaphorum1d
Astellas strikes $1.7bn SIRP drug deal with Elpiscience
Astellas has struck a deal with fellow Japanese pharma company Elpiscience to develop up to four cancer immunotherapies that work by revving up the activity of macrophages against tumour cells.
The EMBO Journal3d
Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation
This study investigates the impact of myenteric neuron-macrophage interactions on postoperative trauma and subsequent ...