ApoB-100’s massive size and association with lipids in LDL have frustrated conventional approaches to studying its detailed structure. Berndsen and Cassidy and Reimund et al. have overcome this ...

The core of the lipoprotein, containing cholesterol ester and TG, is nonpolar and hydrophobic, and the outer layer of the lipoprotein particle (containing free cholesterol, phospholipid ...

ApoB100 is a key protein in normal metabolism and in heart disease. Beginning before the protein’s synthesis is completed, it collects cholesterol and fats into particles that allow these ...

The breakthrough came when the NIH was able to preserve the LDL's structure, creating a sort of freeze-frame that literally trapped LDL in a form of ice that allowed it to be seen by an electron ...

They also carry apolipoproteins that determine both function and structure. Apolipoproteins ... to the assessment of cardiovascular risks, the lipoprotein class-specific concentrations of ...

Study deciphers the molecular handshake between LDL receptors and apoB100, shedding light on cholesterol metabolism and its role in cardiovascular disease. Study: Structure of apolipoprotein B100 ...