These ApoE4 particles cause lysosomes to accumulate lipofuscin, a collection of oxidized lipids and other molecules. The low-risk ApoE2 and Christchurch variants, on the other hand, don’t ferry these ...

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed ...

Introduction: We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two ...

Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada The RPE forms a crucial interface between the neural retina and choroid, the ...

1 Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan 2 Department of Thoracic Surgery, Institute of Development, Aging and ...

Protein and lipid homeostasis is essential for maintaining cellular functions but their crosstalk remains largely unknown. This important manuscript deals with this interesting topic and applies the ...

Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand ...