Previously, we identified mechanosensitive transient receptor potential vanilloid 4 (TRPV4) channels as key regulators of fibrosis and macrophage activation, implicating TRPV4 in AVS as a potential ...

Evaluation of peptide-ligand induced activation of EPDA receptor components was performed 24 h post ... green (split GFP protein), and red (stimulatory peptide patterns) channels were acquired. The ...

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Unlike Wnt, the cystine-knot ligand Norrin only signals through Fzd4 and additionally requires the co-receptor Tetraspanin12 (Tspan12); however, the mechanism underlying Tspan12-mediated signal ...

JBC 2016, the authors described, at atomic details, the conformational changes induced by different cyclic nucleotides on the HCN CNBD fragment and derived energetics associated with ligand binding ..

We were referred an 18-year-old woman with pronounced orthostatic intolerance, gastrointestinal hypomotility, and impaired bladder emptying. In utero, cardiotocography showed fixed heart rates around ...

Over recent years, several studies have suggested the involvement of the purinergic receptor P2X7 (P2X7R), a plasma membrane ionotropic ATP-gated receptor, in the AD brain pathology. In this line, ...

Figure 1. Transmembrane topology and phylogenetic tree of mammalian TRP channels. (A) Transmembrane topology (left) and the quartenary structure of TRP channels (right). The TRP protein has six ...