1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA 2 Department of Chemistry, Princeton University, Princeton, NJ 08544, USA Histone post-translational modifications ...

Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across ...

The findings are published in Science in an article titled, “Nutrient-driven histone code determines exhausted CD8+ T cell fates,” and may lead to new therapies that target these nutrient ...

In the future, the histone code in cells can be developed in a nutrient- and locus-specific manner to manage cellular differentiation. The current study revealed that different expressions of ...

These observations strongly suggested that two major classes of histone modification might act in opposition to help specify a gene regulatory code for the β-globin gene. That is, transcriptional ...

From these differences in overlap, Oren says the histone codes “appear more absolute” whereas mammalian rules seem “more flexible.” Ultimately, Oren's team found this detour away from ...

This enzyme is able to silence specific DNA sections by epigenetically modifying histone proteins that package the DNA. These modifications ensure that the DNA is densely packed as heterochromatin ...