The spatial distribution of glycosylated RNAs in single cells can be imaged using a protocol that uses an aptamer and a DNA probe that are specific for sialic acid-containing glycosylated RNAs.

SHANGHAI, China I January 9, 2025 I Mabwell (688062.SH), an innovative biopharmaceutical company with entire industry chain, announced a significant milestone for its proprietary Nectin-4 targeted ...

Using the company’s proprietary ADC enabling technologies, including but not limited to GlycOBI®, powered by EndoSymeOBI®, OBI has created its novel ADC pipeline, including OBI-992, OBI-902 and ...

Bicycle believes that patients with Nectin-4-associated cancers have the potential to respond ... pretreated breast cancer patients enrolled in the Phase I/II Duravelo-1 clinical trial, eight patients ...

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The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I ...

Safety and tolerability profile was broadly consistent with late-line Duravelo-1 monotherapy and combination ... Since zelenectide pevedotin binds to Nectin-4, it was hypothesized that NECTIN4 ...

We are impressed by the promising preclinical data and the novel mechanism of action of PVR blockade, and we are delighted to join with Nectin Therapeutics to support the Phase 1 trial of NTX1088.” ...